Detailed information of TA system TA110332

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-RHH
• Location: 15496..16031
• Replicon: chromosome
• Accession: NZ_CP031848
• Organism: Marinobacter sp. Arc7-DN-1

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: D0851_RS00090
• Protein ID: WP_117616809.1
• Coordinates: 15496..15792 (-)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: R8AW27
• Locus tag: D0851_RS00095
• Protein ID: WP_012140687.1
• Coordinates: 15792..16031 (-)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D0851_RS00065	11662..13173	+	1512	WP_205422237.1	group II intron reverse transcriptase/maturase	-
D0851_RS20115	13318..13557	+	240	WP_162893650.1	hypothetical protein	-
D0851_RS00075	13832..14011	+	180	WP_048494339.1	type II toxin-antitoxin system HicA family toxin	-
D0851_RS00080	14205..14609	+	405	WP_117616808.1	type II toxin-antitoxin system HicB family antitoxin	-
D0851_RS00085	14901..15398	+	498	Protein_13	group II intron reverse transcriptase/maturase	-
D0851_RS00090	15496..15792	-	297	WP_117616809.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
D0851_RS00095	15792..16031	-	240	WP_012140687.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
D0851_RS00100	16203..16424	+	222	WP_117620215.1	addiction module protein	-
D0851_RS00105	16424..16735	+	312	WP_117616810.1	type II toxin-antitoxin system RelE/ParE family toxin	-
D0851_RS00110	16787..17638	+	852	WP_117616811.1	site-specific integrase	-
D0851_RS00115	17638..18759	+	1122	WP_117620216.1	IS91 family transposase	-
D0851_RS00120	19076..19390	-	315	WP_117616812.1	type II toxin-antitoxin system RelE/ParE family toxin	-
D0851_RS00125	19393..19629	-	237	WP_117616813.1	addiction module protein	-
D0851_RS00135	19882..20394	+	513	Protein_22	hypothetical protein	-
D0851_RS00140	20550..20813	+	264	WP_117616815.1	BrnT family toxin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-92)

Antitoxin

• Antitoxin ParD (4-71)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11528.26 Da
• Isoelectric Point: 7.9223

>T110332 WP_117616809.1 NZ_CP031848:c15792-15496 [Marinobacter sp. Arc7-DN-1]
MPSFKLSRKAKADLKSIALYTEREWGRDQRNHYILQFDQCFHLLGENPNLGQACDEISLGYRQYPQGSHIIFYRLATDDV
VEIIRILHKRMLPEGHLI

Nucleotide

• Length: 297 bp

>T110332 NZ_CP031848:c15792-15496 [Marinobacter sp. Arc7-DN-1]
ATGCCAAGTTTCAAGCTTTCCAGGAAAGCCAAGGCTGACCTCAAATCAATTGCCCTATACACGGAGCGTGAATGGGGCCG
GGATCAACGAAACCACTATATTCTTCAGTTCGATCAATGCTTCCACCTTCTGGGTGAAAATCCAAACCTGGGGCAAGCCT
GCGATGAGATAAGTCTAGGCTACCGGCAGTACCCTCAGGGAAGCCACATCATCTTTTATCGGCTAGCCACCGACGATGTT
GTTGAAATTATCCGCATCCTACACAAACGCATGTTGCCTGAAGGGCATCTGATTTAG

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 9106.06 Da
• Isoelectric Point: 4.6536

>AT110332 WP_012140687.1 NZ_CP031848:c16031-15792 [Marinobacter sp. Arc7-DN-1]
MQKNTSITLGQHFDAFIAEQLKNGRYSSTSEVVRAALRLLEESETRLTTLRKLLKEGEDSGFEDYSYDSFIRELDNEGR

Nucleotide

• Length: 240 bp

>AT110332 NZ_CP031848:c16031-15792 [Marinobacter sp. Arc7-DN-1]
ATGCAAAAGAACACCAGCATCACTTTAGGCCAACATTTTGATGCGTTTATTGCAGAACAGCTCAAAAATGGCCGATACAG
CTCAACCAGCGAGGTCGTTCGTGCCGCATTGCGCCTGCTTGAAGAGTCTGAAACCCGCCTGACTACACTTCGTAAATTGC
TCAAGGAAGGCGAGGACAGTGGTTTCGAAGACTACTCCTATGACTCGTTTATTCGTGAACTGGACAACGAAGGGCGCTGA

Structures

Antitoxin

• AlphaFold DB: R8AW27