Detailed information of TA system
Overview
TA module
Type | II | Classification (family/domain) | relBE/RelE-MqsA |
Location | 3739522..3740221 | Replicon | chromosome |
Accession | NZ_CP031846 | ||
Organism | Proteus mirabilis strain XH983 |
Toxin (Protein)
Gene name | relE | Uniprot ID | - |
Locus tag | D1J70_RS17525 | Protein ID | WP_017628658.1 |
Coordinates | 3739522..3739908 (+) | Length | 129 a.a. |
Antitoxin (Protein)
Gene name | relB | Uniprot ID | B4EZ97 |
Locus tag | D1J70_RS17530 | Protein ID | WP_004246828.1 |
Coordinates | 3739901..3740221 (+) | Length | 107 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
D1J70_RS17510 (D1J70_17600) | 3735541..3736122 | - | 582 | WP_012368524.1 | DNA-3-methyladenine glycosylase I | - |
D1J70_RS17515 (D1J70_17605) | 3736373..3737278 | + | 906 | WP_004246832.1 | glycine--tRNA ligase subunit alpha | - |
D1J70_RS17520 (D1J70_17610) | 3737288..3739360 | + | 2073 | WP_017628659.1 | glycine--tRNA ligase subunit beta | - |
D1J70_RS17525 (D1J70_17615) | 3739522..3739908 | + | 387 | WP_017628658.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
D1J70_RS17530 (D1J70_17620) | 3739901..3740221 | + | 321 | WP_004246828.1 | helix-turn-helix domain-containing protein | Antitoxin |
D1J70_RS17535 (D1J70_17625) | 3740270..3740704 | - | 435 | WP_004246827.1 | hypothetical protein | - |
D1J70_RS17540 (D1J70_17630) | 3740697..3741581 | - | 885 | WP_012368526.1 | endonuclease/exonuclease/phosphatase family protein | - |
D1J70_RS17545 (D1J70_17635) | 3741796..3743082 | - | 1287 | WP_063073863.1 | DUF3748 domain-containing protein | - |
D1J70_RS17550 (D1J70_17640) | 3743219..3743836 | + | 618 | WP_004246822.1 | trimeric intracellular cation channel family protein | - |
D1J70_RS17555 (D1J70_17645) | 3744137..3744760 | + | 624 | WP_004246821.1 | guanylate kinase | - |
D1J70_RS17560 (D1J70_17650) | 3744815..3745090 | + | 276 | WP_004246820.1 | DNA-directed RNA polymerase subunit omega | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 129 a.a. Molecular weight: 14322.65 Da Isoelectric Point: 10.0826
>T110329 WP_017628658.1 NZ_CP031846:3739522-3739908 [Proteus mirabilis]
MVIYKTKMFKNSFKKITLTNAELIAIATEVLAGQFEADLGGGVIKKRACIQGKGKSSGIRTIIFYKQGNNLFFADGWKKS
SLSSKKTKEITDDELESYKDLAKDLFNANQNKIDKMIALGLLTEVRYD
MVIYKTKMFKNSFKKITLTNAELIAIATEVLAGQFEADLGGGVIKKRACIQGKGKSSGIRTIIFYKQGNNLFFADGWKKS
SLSSKKTKEITDDELESYKDLAKDLFNANQNKIDKMIALGLLTEVRYD
Download Length: 387 bp
>T110329 NZ_CP031846:3739522-3739908 [Proteus mirabilis]
ATGGTTATTTATAAAACAAAGATGTTCAAAAATAGTTTCAAAAAAATAACGCTTACGAATGCAGAACTAATCGCTATCGC
TACCGAAGTCCTTGCAGGACAATTTGAGGCAGATCTAGGTGGTGGTGTTATCAAGAAACGTGCCTGTATCCAAGGAAAAG
GTAAAAGTAGCGGAATTAGAACAATTATATTTTATAAGCAAGGGAATAATTTATTCTTTGCTGATGGTTGGAAAAAATCG
AGTTTAAGCTCTAAAAAAACCAAAGAGATCACAGATGATGAACTTGAGTCCTATAAAGATCTAGCAAAAGATCTCTTCAA
TGCAAATCAAAATAAAATAGATAAAATGATTGCACTAGGCCTTTTAACAGAGGTTAGATATGACTGA
ATGGTTATTTATAAAACAAAGATGTTCAAAAATAGTTTCAAAAAAATAACGCTTACGAATGCAGAACTAATCGCTATCGC
TACCGAAGTCCTTGCAGGACAATTTGAGGCAGATCTAGGTGGTGGTGTTATCAAGAAACGTGCCTGTATCCAAGGAAAAG
GTAAAAGTAGCGGAATTAGAACAATTATATTTTATAAGCAAGGGAATAATTTATTCTTTGCTGATGGTTGGAAAAAATCG
AGTTTAAGCTCTAAAAAAACCAAAGAGATCACAGATGATGAACTTGAGTCCTATAAAGATCTAGCAAAAGATCTCTTCAA
TGCAAATCAAAATAAAATAGATAAAATGATTGCACTAGGCCTTTTAACAGAGGTTAGATATGACTGA
Antitoxin
Download Length: 107 a.a. Molecular weight: 12126.21 Da Isoelectric Point: 10.4411
>AT110329 WP_004246828.1 NZ_CP031846:3739901-3740221 [Proteus mirabilis]
MTDKMKEMLKFAQEMEDAGVTDGSTTKRIAARIKAKELQAKYKHPTPMTGEDIKRIREQNNISQSSLALILNMTKESVSK
WERNEIKPNGAALRLLHLIDKKILFI
MTDKMKEMLKFAQEMEDAGVTDGSTTKRIAARIKAKELQAKYKHPTPMTGEDIKRIREQNNISQSSLALILNMTKESVSK
WERNEIKPNGAALRLLHLIDKKILFI
Download Length: 321 bp
>AT110329 NZ_CP031846:3739901-3740221 [Proteus mirabilis]
ATGACTGATAAAATGAAAGAAATGCTAAAATTTGCACAAGAAATGGAAGATGCAGGAGTCACTGATGGCAGTACAACTAA
ACGTATTGCCGCCAGAATAAAAGCGAAAGAATTACAGGCTAAGTATAAACATCCTACCCCTATGACAGGTGAAGATATAA
AAAGGATCCGTGAGCAAAATAATATCTCTCAATCTTCCCTTGCTTTGATATTGAATATGACTAAAGAAAGCGTTTCTAAG
TGGGAAAGAAACGAAATTAAGCCCAATGGTGCAGCACTACGACTTCTGCATTTAATAGATAAAAAAATATTATTCATCTA
G
ATGACTGATAAAATGAAAGAAATGCTAAAATTTGCACAAGAAATGGAAGATGCAGGAGTCACTGATGGCAGTACAACTAA
ACGTATTGCCGCCAGAATAAAAGCGAAAGAATTACAGGCTAAGTATAAACATCCTACCCCTATGACAGGTGAAGATATAA
AAAGGATCCGTGAGCAAAATAATATCTCTCAATCTTCCCTTGCTTTGATATTGAATATGACTAAAGAAAGCGTTTCTAAG
TGGGAAAGAAACGAAATTAAGCCCAATGGTGCAGCACTACGACTTCTGCATTTAATAGATAAAAAAATATTATTCATCTA
G
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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