Detailed information of TA system TA110329

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-MqsA
• Location: 3739522..3740221
• Replicon: chromosome
• Accession: NZ_CP031846
• Organism: Proteus mirabilis strain XH983

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: D1J70_RS17525
• Protein ID: WP_017628658.1
• Coordinates: 3739522..3739908 (+)
• Length: 129 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: B4EZ97
• Locus tag: D1J70_RS17530
• Protein ID: WP_004246828.1
• Coordinates: 3739901..3740221 (+)
• Length: 107 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D1J70_RS17510 (D1J70_17600)	3735541..3736122	-	582	WP_012368524.1	DNA-3-methyladenine glycosylase I	-
D1J70_RS17515 (D1J70_17605)	3736373..3737278	+	906	WP_004246832.1	glycine--tRNA ligase subunit alpha	-
D1J70_RS17520 (D1J70_17610)	3737288..3739360	+	2073	WP_017628659.1	glycine--tRNA ligase subunit beta	-
D1J70_RS17525 (D1J70_17615)	3739522..3739908	+	387	WP_017628658.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
D1J70_RS17530 (D1J70_17620)	3739901..3740221	+	321	WP_004246828.1	helix-turn-helix domain-containing protein	Antitoxin
D1J70_RS17535 (D1J70_17625)	3740270..3740704	-	435	WP_004246827.1	hypothetical protein	-
D1J70_RS17540 (D1J70_17630)	3740697..3741581	-	885	WP_012368526.1	endonuclease/exonuclease/phosphatase family protein	-
D1J70_RS17545 (D1J70_17635)	3741796..3743082	-	1287	WP_063073863.1	DUF3748 domain-containing protein	-
D1J70_RS17550 (D1J70_17640)	3743219..3743836	+	618	WP_004246822.1	trimeric intracellular cation channel family protein	-
D1J70_RS17555 (D1J70_17645)	3744137..3744760	+	624	WP_004246821.1	guanylate kinase	-
D1J70_RS17560 (D1J70_17650)	3744815..3745090	+	276	WP_004246820.1	DNA-directed RNA polymerase subunit omega	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (1-125)

Antitoxin

• Cro/C1-type helix-turn-helix domain (53-95)

Sequences

Toxin

Protein

• Length: 129 a.a.
• Molecular weight: 14322.65 Da
• Isoelectric Point: 10.0826

>T110329 WP_017628658.1 NZ_CP031846:3739522-3739908 [Proteus mirabilis]
MVIYKTKMFKNSFKKITLTNAELIAIATEVLAGQFEADLGGGVIKKRACIQGKGKSSGIRTIIFYKQGNNLFFADGWKKS
SLSSKKTKEITDDELESYKDLAKDLFNANQNKIDKMIALGLLTEVRYD

Nucleotide

• Length: 387 bp

>T110329 NZ_CP031846:3739522-3739908 [Proteus mirabilis]
ATGGTTATTTATAAAACAAAGATGTTCAAAAATAGTTTCAAAAAAATAACGCTTACGAATGCAGAACTAATCGCTATCGC
TACCGAAGTCCTTGCAGGACAATTTGAGGCAGATCTAGGTGGTGGTGTTATCAAGAAACGTGCCTGTATCCAAGGAAAAG
GTAAAAGTAGCGGAATTAGAACAATTATATTTTATAAGCAAGGGAATAATTTATTCTTTGCTGATGGTTGGAAAAAATCG
AGTTTAAGCTCTAAAAAAACCAAAGAGATCACAGATGATGAACTTGAGTCCTATAAAGATCTAGCAAAAGATCTCTTCAA
TGCAAATCAAAATAAAATAGATAAAATGATTGCACTAGGCCTTTTAACAGAGGTTAGATATGACTGA

Antitoxin

Protein

• Length: 107 a.a.
• Molecular weight: 12126.21 Da
• Isoelectric Point: 10.4411

>AT110329 WP_004246828.1 NZ_CP031846:3739901-3740221 [Proteus mirabilis]
MTDKMKEMLKFAQEMEDAGVTDGSTTKRIAARIKAKELQAKYKHPTPMTGEDIKRIREQNNISQSSLALILNMTKESVSK
WERNEIKPNGAALRLLHLIDKKILFI

Nucleotide

• Length: 321 bp

>AT110329 NZ_CP031846:3739901-3740221 [Proteus mirabilis]
ATGACTGATAAAATGAAAGAAATGCTAAAATTTGCACAAGAAATGGAAGATGCAGGAGTCACTGATGGCAGTACAACTAA
ACGTATTGCCGCCAGAATAAAAGCGAAAGAATTACAGGCTAAGTATAAACATCCTACCCCTATGACAGGTGAAGATATAA
AAAGGATCCGTGAGCAAAATAATATCTCTCAATCTTCCCTTGCTTTGATATTGAATATGACTAAAGAAAGCGTTTCTAAG
TGGGAAAGAAACGAAATTAAGCCCAATGGTGCAGCACTACGACTTCTGCATTTAATAGATAAAAAAATATTATTCATCTA
G

Structures

Antitoxin

• AlphaFold DB: B4EZ97