Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/PRK09812-MazE
Location 910458..911047 Replicon chromosome
Accession NZ_CP031844
Organism Bartonella krasnovii strain OE 1-1

Toxin (Protein)


Gene name pemK Uniprot ID -
Locus tag D1092_RS03820 Protein ID WP_120122258.1
Coordinates 910715..911047 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID -
Locus tag D1092_RS03815 Protein ID WP_120122257.1
Coordinates 910458..910715 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D1092_RS03785 905740..906927 + 1188 WP_120122252.1 DUF1376 domain-containing protein -
D1092_RS09610 906911..907291 + 381 WP_174767382.1 hypothetical protein -
D1092_RS03795 907474..907983 + 510 WP_120122253.1 hypothetical protein -
D1092_RS03800 908232..909095 + 864 WP_120122254.1 hypothetical protein -
D1092_RS03805 909371..909814 + 444 WP_120122255.1 single-stranded DNA-binding protein -
D1092_RS03810 909869..910363 + 495 WP_120122256.1 hypothetical protein -
D1092_RS03815 910458..910715 + 258 WP_120122257.1 antitoxin Antitoxin
D1092_RS03820 910715..911047 + 333 WP_120122258.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
D1092_RS03825 911235..911945 - 711 WP_120122259.1 hypothetical protein -
D1092_RS03835 912253..912588 + 336 WP_120122260.1 hypothetical protein -
D1092_RS03840 912569..913894 + 1326 WP_120122261.1 phage terminase large subunit -
D1092_RS03845 913879..915927 + 2049 WP_120122262.1 phage portal protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 855834..932752 76918


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-109)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 11853.95 Da        Isoelectric Point: 10.5590

>T110322 WP_120122258.1 NZ_CP031844:910715-911047 [Bartonella krasnovii]
MKRGEIWLVSLDPSSGYEQKGTRPVLIVSPEAFNRVTKTPIVLPITSGGNFARTAGFAVSLMGVGLHTTGVIRCDQPRAL
DIGARQGKKMETVPPMIMNEVLAKLATFLT

Download         Length: 333 bp

>T110322 NZ_CP031844:910715-911047 [Bartonella krasnovii]
ATGAAGCGGGGAGAGATTTGGCTTGTATCTCTTGACCCATCTTCGGGTTATGAACAAAAAGGAACGCGTCCTGTACTGAT
TGTATCACCAGAAGCGTTTAATCGTGTAACGAAAACACCTATTGTCTTGCCTATTACAAGCGGGGGGAATTTTGCTAGAA
CAGCAGGTTTTGCTGTCTCATTAATGGGAGTAGGATTGCATACAACAGGCGTGATACGTTGTGACCAGCCACGTGCTCTT
GATATTGGAGCGCGTCAGGGTAAAAAAATGGAAACAGTTCCCCCTATGATAATGAACGAAGTTCTTGCTAAGCTAGCAAC
ATTTCTCACGTAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9346.69 Da        Isoelectric Point: 3.8857

>AT110322 WP_120122257.1 NZ_CP031844:910458-910715 [Bartonella krasnovii]
MYTTKLRKVGGSVMLSIPPVLLDVLHLTENTQVGLAVDNGQLIVKPQTFPSYTLDELLAQCNPSVDFADEDIEWFDAQPV
GSELL

Download         Length: 258 bp

>AT110322 NZ_CP031844:910458-910715 [Bartonella krasnovii]
ATGTATACAACAAAATTACGTAAAGTTGGAGGGTCAGTGATGCTTTCTATACCACCTGTCTTGCTTGATGTTCTCCATCT
TACTGAAAACACACAAGTGGGCTTGGCTGTTGATAATGGACAATTGATTGTGAAGCCACAAACATTTCCAAGTTACACTC
TTGATGAATTATTAGCCCAATGTAATCCTTCAGTTGATTTTGCGGATGAGGATATAGAGTGGTTTGATGCTCAACCTGTT
GGTAGCGAGCTTTTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References