Detailed information of TA system TA110321

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pasABC/RelE-HTH
• Location: 1659694..1660174
• Replicon: chromosome
• Accession: NZ_CP031843
• Organism: Bartonella kosoyi strain Tel Aviv

Toxin (Protein)

• Gene name: pasB
• Uniprot ID: -
• Locus tag: D1093_RS07300
• Protein ID: WP_120100673.1
• Coordinates: 1659694..1659963 (-)
• Length: 90 a.a.

Antitoxin (Protein)

• Gene name: pasA
• Uniprot ID: -
• Locus tag: D1093_RS07305
• Protein ID: WP_120100671.1
• Coordinates: 1659947..1660174 (-)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D1093_RS07280	1654930..1655820	-	891	WP_120102306.1	hypothetical protein	-
D1093_RS07285	1655846..1657864	-	2019	WP_120100677.1	phage portal protein	-
D1093_RS07290	1657849..1659177	-	1329	WP_120100676.1	phage terminase large subunit	-
D1093_RS07295	1659158..1659493	-	336	WP_120100674.1	hypothetical protein	-
D1093_RS07300	1659694..1659963	-	270	WP_120100673.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
D1093_RS07305	1659947..1660174	-	228	WP_120100671.1	ribbon-helix-helix protein, CopG family	Antitoxin
D1093_RS07310	1660269..1660703	-	435	WP_120101671.1	hypothetical protein	-
D1093_RS07315	1660915..1662081	+	1167	WP_120101673.1	site-specific integrase	-
D1093_RS07320	1662291..1662491	+	201	WP_120100668.1	DNA-binding protein	-
D1093_RS07325	1662712..1663115	-	404	Protein_1395	hypothetical protein	-
D1093_RS07330	1663112..1664524	-	1413	WP_150222358.1	filamentous hemagglutinin	-
D1093_RS07335	1664601..1665014	-	414	WP_120100876.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1636114..1663115	27001

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-87)

Antitoxin

• Protein of unknown function DUF6290 (2-71)

Sequences

Toxin

Protein

• Length: 90 a.a.
• Molecular weight: 10447.35 Da
• Isoelectric Point: 10.2298

>T110321 WP_120100673.1 NZ_CP031843:c1659963-1659694 [Bartonella kosoyi]
MAWTIRYERKALSFLKKCDKKEARRIVDFLDQHVAPLEDVRAIGKPLKGQLSGLWRYRVGDYRILCDLYDKELVVLVLAV
GHRKNIYKG

Nucleotide

• Length: 270 bp

>T110321 NZ_CP031843:c1659963-1659694 [Bartonella kosoyi]
TTGGCTTGGACGATTAGATATGAAAGAAAAGCTCTTAGTTTTTTAAAAAAATGCGATAAAAAAGAAGCACGGAGGATTGT
TGATTTTTTAGATCAACACGTTGCCCCTCTTGAAGATGTACGTGCAATAGGTAAGCCCTTAAAAGGGCAATTATCGGGTT
TATGGAGATATCGTGTAGGAGATTACAGAATACTTTGCGATCTTTATGATAAGGAACTTGTTGTGTTAGTTTTAGCTGTT
GGACATAGAAAAAATATATATAAAGGCTAA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8800.86 Da
• Isoelectric Point: 4.8898

>AT110321 WP_120100671.1 NZ_CP031843:c1660174-1659947 [Bartonella kosoyi]
MTISIRLPSELETRLNNLATKTGRTKSFYLREIIERGIEEAEDYYLASQVRERVRRGEATFYSSEEVRKELGLDD

Nucleotide

• Length: 228 bp

>AT110321 NZ_CP031843:c1660174-1659947 [Bartonella kosoyi]
ATGACGATATCTATTCGATTGCCTAGCGAACTTGAAACACGTTTGAATAATTTAGCAACTAAGACAGGTCGTACAAAGTC
TTTTTATTTACGTGAGATTATTGAACGTGGAATCGAGGAAGCTGAGGATTATTATTTAGCTTCACAAGTAAGAGAGCGTG
TTCGAAGAGGAGAAGCTACTTTTTATAGCTCTGAAGAGGTGAGGAAAGAGCTTGGCTTGGACGATTAG