Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-DUF971
Location 1652305..1652878 Replicon chromosome
Accession NZ_CP031843
Organism Bartonella kosoyi strain Tel Aviv

Toxin (Protein)


Gene name PumA Uniprot ID A0A5B9CX33
Locus tag D1093_RS07255 Protein ID WP_012232364.1
Coordinates 1652305..1652613 (+) Length 103 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID A0A5B9CYS4
Locus tag D1093_RS07260 Protein ID WP_012232365.1
Coordinates 1652594..1652878 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D1093_RS07230 1648025..1648750 - 726 WP_120101668.1 hypothetical protein -
D1093_RS07235 1648762..1649646 - 885 WP_120101670.1 hypothetical protein -
D1093_RS07240 1649648..1650073 - 426 WP_120100686.1 hypothetical protein -
D1093_RS07245 1650073..1651530 - 1458 WP_120100684.1 hypothetical protein -
D1093_RS07250 1651532..1652239 - 708 WP_012232363.1 hypothetical protein -
D1093_RS07255 1652305..1652613 + 309 WP_012232364.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
D1093_RS07260 1652594..1652878 + 285 WP_012232365.1 putative addiction module antidote protein Antitoxin
D1093_RS07265 1652914..1653294 - 381 WP_120100682.1 hypothetical protein -
D1093_RS07270 1653306..1653686 - 381 WP_120100681.1 hypothetical protein -
D1093_RS07275 1653709..1654836 - 1128 WP_120100679.1 N4-gp56 family major capsid protein -
D1093_RS07280 1654930..1655820 - 891 WP_120102306.1 hypothetical protein -
D1093_RS07285 1655846..1657864 - 2019 WP_120100677.1 phage portal protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1636114..1663115 27001


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-95)

Antitoxin

Uncharacterized protein HI1420

(3-89)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11876.83 Da        Isoelectric Point: 9.9055

>T110320 WP_012232364.1 NZ_CP031843:1652305-1652613 [Bartonella kosoyi]
MIFIHKTIEFDNWLKKLKDKKAKAIILQRVVRLKQGLLGDVKFFNSIGEVRIHYGAGYRIYFTQKGSDFILLLCGGDKST
QQRDIEQALKLKEEYSDENNPI

Download         Length: 309 bp

>T110320 NZ_CP031843:1652305-1652613 [Bartonella kosoyi]
ATGATATTCATTCATAAAACGATAGAATTTGATAATTGGCTTAAGAAACTCAAAGATAAAAAGGCTAAAGCGATTATTCT
TCAACGTGTTGTACGCTTAAAACAAGGACTTTTGGGTGATGTTAAGTTCTTCAATAGCATAGGTGAAGTACGCATCCACT
ATGGTGCTGGTTACAGAATTTATTTTACCCAAAAAGGCTCTGATTTTATCCTTTTGTTATGTGGTGGAGATAAATCAACG
CAGCAAAGGGATATCGAACAAGCGTTAAAGTTAAAAGAGGAGTACAGTGATGAAAACAACCCCATTTAA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10329.73 Da        Isoelectric Point: 7.0111

>AT110320 WP_012232365.1 NZ_CP031843:1652594-1652878 [Bartonella kosoyi]
MKTTPFKPEEYLEDIEVQQAFLNEAFKTGDAAHIADAIGIVARSQNMRALAKETNRERSGLYRSLSKTGDPKLSTLVAVL
SALNLQLFVQSSTS

Download         Length: 285 bp

>AT110320 NZ_CP031843:1652594-1652878 [Bartonella kosoyi]
ATGAAAACAACCCCATTTAAACCAGAAGAATATCTTGAAGACATTGAAGTACAACAAGCATTTCTCAATGAAGCCTTCAA
AACTGGTGATGCCGCTCATATAGCGGATGCCATTGGTATCGTTGCTCGCTCTCAAAATATGCGTGCTTTAGCAAAAGAAA
CCAATCGCGAACGCAGTGGATTATATCGCTCCTTAAGTAAAACGGGTGACCCCAAGCTTTCTACTTTAGTCGCTGTCTTA
TCTGCCCTTAACCTGCAACTCTTTGTACAGTCTTCTACTTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5B9CX33

Antitoxin

Source ID Structure
AlphaFold DB A0A5B9CYS4

References