Detailed information of TA system TA110318

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pemIK/PRK09812-MazE
• Location: 1453526..1454115
• Replicon: chromosome
• Accession: NZ_CP031843
• Organism: Bartonella kosoyi strain Tel Aviv

Toxin (Protein)

• Gene name: pemK
• Uniprot ID: -
• Locus tag: D1093_RS06320
• Protein ID: WP_120101425.1
• Coordinates: 1453783..1454115 (+)
• Length: 111 a.a.

Antitoxin (Protein)

• Gene name: pemI
• Uniprot ID: -
• Locus tag: D1093_RS06315
• Protein ID: WP_120101424.1
• Coordinates: 1453526..1453783 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D1093_RS06275	1448907..1449386	+	480	WP_120101408.1	hypothetical protein	-
D1093_RS06280	1449376..1450521	+	1146	WP_120101410.1	DUF1376 domain-containing protein	-
D1093_RS06285	1450496..1450891	+	396	WP_120101412.1	hypothetical protein	-
D1093_RS06290	1451072..1451539	+	468	WP_120101414.1	hypothetical protein	-
D1093_RS06295	1451637..1451942	-	306	WP_120101416.1	BrnA antitoxin family protein	-
D1093_RS06300	1451920..1452219	-	300	WP_120101418.1	BrnT family toxin	-
D1093_RS06305	1452436..1452882	+	447	WP_120101420.1	single-stranded DNA-binding protein	-
D1093_RS06310	1452936..1453430	+	495	WP_120101422.1	hypothetical protein	-
D1093_RS06315	1453526..1453783	+	258	WP_120101424.1	antitoxin	Antitoxin
D1093_RS06320	1453783..1454115	+	333	WP_120101425.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
D1093_RS06325	1454229..1454456	+	228	WP_120101427.1	ribbon-helix-helix protein, CopG family	-
D1093_RS06330	1454720..1455736	-	1017	WP_100129667.1	hypothetical protein	-
D1093_RS06340	1456048..1456374	+	327	WP_120101428.1	hypothetical protein	-
D1093_RS06345	1456355..1457680	+	1326	WP_120101430.1	phage terminase large subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1436513..1475285	38772

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (2-108)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 111 a.a.
• Molecular weight: 11892.00 Da
• Isoelectric Point: 10.6625

>T110318 WP_120101425.1 NZ_CP031843:1453783-1454115 [Bartonella kosoyi]
MKRGEIWLVSLDPSSGYEQKGTRPVLIVSPEPFNRVTKTPIVLPITSGGNFARTAGFAVSLMGVGLHTTGVIRCDQPRAL
DIAARQGKRMEAVPPMIMNEVLAKLATFLT

Nucleotide

• Length: 333 bp

>T110318 NZ_CP031843:1453783-1454115 [Bartonella kosoyi]
ATGAAGCGAGGCGAAATTTGGCTTGTATCTCTTGATCCATCTTCGGGTTATGAACAAAAAGGAACGCGTCCTGTATTAAT
TGTGTCACCAGAGCCATTTAATCGTGTAACAAAAACACCTATTGTCTTGCCTATTACAAGCGGAGGAAATTTTGCGAGAA
CCGCAGGGTTTGCTGTTTCATTAATGGGAGTGGGATTACATACAACAGGTGTGATACGTTGTGATCAACCACGTGCTCTC
GATATAGCAGCGCGTCAGGGGAAGAGAATGGAAGCAGTTCCCCCCATGATTATGAACGAAGTCCTTGCTAAACTAGCAAC
ATTTCTTACGTAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9416.81 Da
• Isoelectric Point: 4.3547

>AT110318 WP_120101424.1 NZ_CP031843:1453526-1453783 [Bartonella kosoyi]
MHTTKLRKVGGSVMLSIPPALLDVLHLTENTQVGLAIDNGRLIVKPQSLPNYTLEELLAQCNPSDDFADDDMEWFDAKPV
GRELL

Nucleotide

• Length: 258 bp

>AT110318 NZ_CP031843:1453526-1453783 [Bartonella kosoyi]
ATGCACACAACAAAATTACGTAAGGTTGGTGGGTCTGTTATGCTCTCTATACCGCCGGCATTACTTGATGTTCTTCATCT
TACTGAAAACACGCAAGTGGGTTTAGCTATTGATAATGGACGATTGATTGTAAAGCCACAGTCACTACCAAATTACACTC
TTGAAGAATTGTTAGCGCAATGTAATCCTTCGGACGATTTTGCGGATGATGATATGGAATGGTTTGATGCTAAACCTGTT
GGTAGAGAGCTGTTGTGA