Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-DUF971
Location 792637..793210 Replicon chromosome
Accession NZ_CP031843
Organism Bartonella kosoyi strain Tel Aviv

Toxin (Protein)


Gene name PumA Uniprot ID A0A5B9CX33
Locus tag D1093_RS03430 Protein ID WP_012232364.1
Coordinates 792902..793210 (-) Length 103 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID A0A5B9CYS4
Locus tag D1093_RS03425 Protein ID WP_012232365.1
Coordinates 792637..792921 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D1093_RS03400 787651..789669 + 2019 WP_120100677.1 phage portal protein -
D1093_RS03405 789695..790585 + 891 WP_120102306.1 hypothetical protein -
D1093_RS03410 790679..791806 + 1128 WP_120100679.1 N4-gp56 family major capsid protein -
D1093_RS03415 791829..792209 + 381 WP_120100681.1 hypothetical protein -
D1093_RS03420 792221..792601 + 381 WP_120100682.1 hypothetical protein -
D1093_RS03425 792637..792921 - 285 WP_012232365.1 putative addiction module antidote protein Antitoxin
D1093_RS03430 792902..793210 - 309 WP_012232364.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
D1093_RS03435 793276..793983 + 708 WP_012232363.1 hypothetical protein -
D1093_RS03440 793985..795442 + 1458 WP_120100684.1 hypothetical protein -
D1093_RS03445 795442..795867 + 426 WP_120100686.1 hypothetical protein -
D1093_RS03450 795869..796792 + 924 WP_120100687.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 686506..811189 124683


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-95)

Antitoxin

Uncharacterized protein HI1420

(3-89)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11876.83 Da        Isoelectric Point: 9.9055

>T110316 WP_012232364.1 NZ_CP031843:c793210-792902 [Bartonella kosoyi]
MIFIHKTIEFDNWLKKLKDKKAKAIILQRVVRLKQGLLGDVKFFNSIGEVRIHYGAGYRIYFTQKGSDFILLLCGGDKST
QQRDIEQALKLKEEYSDENNPI

Download         Length: 309 bp

>T110316 NZ_CP031843:c793210-792902 [Bartonella kosoyi]
ATGATATTCATTCATAAAACGATAGAATTTGATAATTGGCTTAAGAAACTCAAAGATAAAAAGGCTAAAGCGATTATTCT
TCAACGTGTTGTACGCTTAAAACAAGGACTTTTGGGTGATGTTAAGTTCTTCAATAGCATAGGTGAAGTACGCATCCACT
ATGGTGCTGGTTACAGAATTTATTTTACCCAAAAAGGCTCTGATTTTATCCTTTTGTTATGTGGTGGAGATAAATCAACG
CAGCAAAGGGATATCGAACAAGCGTTAAAGTTAAAAGAGGAGTACAGTGATGAAAACAACCCCATTTAA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10329.73 Da        Isoelectric Point: 7.0111

>AT110316 WP_012232365.1 NZ_CP031843:c792921-792637 [Bartonella kosoyi]
MKTTPFKPEEYLEDIEVQQAFLNEAFKTGDAAHIADAIGIVARSQNMRALAKETNRERSGLYRSLSKTGDPKLSTLVAVL
SALNLQLFVQSSTS

Download         Length: 285 bp

>AT110316 NZ_CP031843:c792921-792637 [Bartonella kosoyi]
ATGAAAACAACCCCATTTAAACCAGAAGAATATCTTGAAGACATTGAAGTACAACAAGCATTTCTCAATGAAGCCTTCAA
AACTGGTGATGCCGCTCATATAGCGGATGCCATTGGTATCGTTGCTCGCTCTCAAAATATGCGTGCTTTAGCAAAAGAAA
CCAATCGCGAACGCAGTGGATTATATCGCTCCTTAAGTAAAACGGGTGACCCCAAGCTTTCTACTTTAGTCGCTGTCTTA
TCTGCCCTTAACCTGCAACTCTTTGTACAGTCTTCTACTTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5B9CX33

Antitoxin

Source ID Structure
AlphaFold DB A0A5B9CYS4

References