Detailed information of TA system TA110315

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pasABC/RelE-HTH
• Location: 785341..785821
• Replicon: chromosome
• Accession: NZ_CP031843
• Organism: Bartonella kosoyi strain Tel Aviv

Toxin (Protein)

• Gene name: pasB
• Uniprot ID: -
• Locus tag: D1093_RS03385
• Protein ID: WP_120100673.1
• Coordinates: 785552..785821 (+)
• Length: 90 a.a.

Antitoxin (Protein)

• Gene name: pasA
• Uniprot ID: -
• Locus tag: D1093_RS03380
• Protein ID: WP_120100671.1
• Coordinates: 785341..785568 (+)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D1093_RS03360	782400..782803	+	404	Protein_636	hypothetical protein	-
D1093_RS03365	783024..783224	-	201	WP_120100668.1	DNA-binding protein	-
D1093_RS03370	783434..784600	-	1167	WP_120101673.1	site-specific integrase	-
D1093_RS03375	784812..785246	+	435	WP_120101671.1	hypothetical protein	-
D1093_RS03380	785341..785568	+	228	WP_120100671.1	ribbon-helix-helix protein, CopG family	Antitoxin
D1093_RS03385	785552..785821	+	270	WP_120100673.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
D1093_RS03390	786022..786357	+	336	WP_120100674.1	hypothetical protein	-
D1093_RS03395	786338..787666	+	1329	WP_120100676.1	phage terminase large subunit	-
D1093_RS03400	787651..789669	+	2019	WP_120100677.1	phage portal protein	-
D1093_RS03405	789695..790585	+	891	WP_120102306.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	686506..811189	124683

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-87)

Antitoxin

• Protein of unknown function DUF6290 (2-71)

Sequences

Toxin

Protein

• Length: 90 a.a.
• Molecular weight: 10447.35 Da
• Isoelectric Point: 10.2298

>T110315 WP_120100673.1 NZ_CP031843:785552-785821 [Bartonella kosoyi]
MAWTIRYERKALSFLKKCDKKEARRIVDFLDQHVAPLEDVRAIGKPLKGQLSGLWRYRVGDYRILCDLYDKELVVLVLAV
GHRKNIYKG

Nucleotide

• Length: 270 bp

>T110315 NZ_CP031843:785552-785821 [Bartonella kosoyi]
TTGGCTTGGACGATTAGATATGAAAGAAAAGCTCTTAGTTTTTTAAAAAAATGCGATAAAAAAGAAGCACGGAGGATTGT
TGATTTTTTAGATCAACACGTTGCCCCTCTTGAAGATGTACGTGCAATAGGTAAGCCCTTAAAAGGGCAATTATCGGGTT
TATGGAGATATCGTGTAGGAGATTACAGAATACTTTGCGATCTTTATGATAAGGAACTTGTTGTGTTAGTTTTAGCTGTT
GGACATAGAAAAAATATATATAAAGGCTAA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8800.86 Da
• Isoelectric Point: 4.8898

>AT110315 WP_120100671.1 NZ_CP031843:785341-785568 [Bartonella kosoyi]
MTISIRLPSELETRLNNLATKTGRTKSFYLREIIERGIEEAEDYYLASQVRERVRRGEATFYSSEEVRKELGLDD

Nucleotide

• Length: 228 bp

>AT110315 NZ_CP031843:785341-785568 [Bartonella kosoyi]
ATGACGATATCTATTCGATTGCCTAGCGAACTTGAAACACGTTTGAATAATTTAGCAACTAAGACAGGTCGTACAAAGTC
TTTTTATTTACGTGAGATTATTGAACGTGGAATCGAGGAAGCTGAGGATTATTATTTAGCTTCACAAGTAAGAGAGCGTG
TTCGAAGAGGAGAAGCTACTTTTTATAGCTCTGAAGAGGTGAGGAAAGAGCTTGGCTTGGACGATTAG