Detailed information of TA system TA110314

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RelE-RHH
• Location: 776327..776886
• Replicon: chromosome
• Accession: NZ_CP031843
• Organism: Bartonella kosoyi strain Tel Aviv

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: D1093_RS03335
• Protein ID: WP_120100665.1
• Coordinates: 776327..776599 (-)
• Length: 91 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A5B9CWB1
• Locus tag: D1093_RS03340
• Protein ID: WP_012231079.1
• Coordinates: 776596..776886 (-)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D1093_RS03330	775178..776146	-	969	WP_120100664.1	DUF3987 domain-containing protein	-
D1093_RS03335	776327..776599	-	273	WP_120100665.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
D1093_RS03340	776596..776886	-	291	WP_012231079.1	hypothetical protein	Antitoxin
D1093_RS03345	777463..777663	-	201	WP_007347430.1	DNA-binding protein	-
D1093_RS03350	777873..779039	-	1167	WP_120100666.1	site-specific integrase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	686506..811189	124683

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-89)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 91 a.a.
• Molecular weight: 10623.59 Da
• Isoelectric Point: 10.7758

>T110314 WP_120100665.1 NZ_CP031843:c776599-776327 [Bartonella kosoyi]
MKLIWTQVARVDRKKIREYISQDNPSAALKFDQLLSEKIEKLVKFPTLGRLGRVVNTREFIVHPNYIMIYDISDGVVRIL
RVLHTKQKFP

Nucleotide

• Length: 273 bp

>T110314 NZ_CP031843:c776599-776327 [Bartonella kosoyi]
ATGAAGCTAATTTGGACACAAGTAGCACGCGTTGACCGCAAAAAGATACGTGAATACATATCACAAGATAATCCTTCTGC
TGCCTTAAAGTTTGATCAACTTTTATCTGAAAAGATAGAAAAACTCGTTAAGTTTCCTACTCTTGGTCGTTTAGGACGAG
TTGTAAATACACGTGAATTTATTGTACATCCAAATTATATCATGATTTATGATATTTCAGATGGCGTTGTTCGTATTTTA
CGTGTGCTTCATACAAAGCAAAAATTCCCTTAA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 11078.46 Da
• Isoelectric Point: 5.2356

>AT110314 WP_012231079.1 NZ_CP031843:c776886-776596 [Bartonella kosoyi]
MAETTFTFRVDDVLKNEFSKAAKACDRSGAQLLRDYMRDIVKEQKERSAHDLWFREQVQLGINSANAGDIISSEEIEAEA
KEWRLKIQSKLDRSTL

Nucleotide

• Length: 291 bp

>AT110314 NZ_CP031843:c776886-776596 [Bartonella kosoyi]
ATGGCTGAGACGACATTTACCTTTCGCGTTGATGATGTATTGAAAAATGAATTTTCCAAAGCAGCAAAAGCGTGTGATAG
ATCTGGTGCACAATTGTTGCGAGATTATATGCGCGATATCGTAAAAGAACAAAAAGAAAGAAGTGCACACGATTTATGGT
TTCGGGAACAGGTTCAATTAGGGATAAATTCTGCTAATGCAGGCGATATAATATCTTCTGAGGAAATCGAAGCAGAAGCA
AAGGAATGGCGCTTAAAAATACAAAGTAAACTAGATAGATCAACTTTATGA

Structures

Antitoxin

• AlphaFold DB: A0A5B9CWB1