Detailed information of TA system TA110313

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-dinJ/YafQ-RelB
• Location: 726913..727444
• Replicon: chromosome
• Accession: NZ_CP031843
• Organism: Bartonella kosoyi strain Tel Aviv

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: D1093_RS03015
• Protein ID: WP_120100599.1
• Coordinates: 727163..727444 (+)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: dinJ
• Uniprot ID: -
• Locus tag: D1093_RS03010
• Protein ID: WP_100129267.1
• Coordinates: 726913..727176 (+)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D1093_RS02985	723411..723659	-	249	WP_120100590.1	hypothetical protein	-
D1093_RS02990	723663..725594	-	1932	WP_120100592.1	phage terminase large subunit family protein	-
D1093_RS02995	725625..726176	-	552	WP_120100594.1	hypothetical protein	-
D1093_RS03000	726261..726527	+	267	WP_120100595.1	BrnT family toxin	-
D1093_RS03005	726505..726810	+	306	WP_120100597.1	BrnA antitoxin family protein	-
D1093_RS03010	726913..727176	+	264	WP_100129267.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
D1093_RS03015	727163..727444	+	282	WP_120100599.1	type II toxin-antitoxin system YafQ family toxin	Toxin
D1093_RS03020	727500..727778	-	279	WP_120100601.1	hypothetical protein	-
D1093_RS03025	727775..728518	-	744	WP_120100602.1	antA/AntB antirepressor family protein	-
D1093_RS09900	728601..728759	-	159	WP_167309083.1	hypothetical protein	-
D1093_RS03035	729116..729694	-	579	WP_120100607.1	hypothetical protein	-
D1093_RS03040	729698..730018	-	321	WP_120100609.1	hypothetical protein	-
D1093_RS03045	730370..730552	+	183	WP_038473319.1	type II toxin-antitoxin system HicA family toxin	-
D1093_RS03050	730573..730995	+	423	WP_012231075.1	hypothetical protein	-
D1093_RS03055	730999..731541	-	543	WP_120100610.1	hypothetical protein	-
D1093_RS03060	731552..731995	-	444	WP_120100612.1	single-stranded DNA-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	686506..811189	124683

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-91)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-83)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 11197.01 Da
• Isoelectric Point: 10.3619

>T110313 WP_120100599.1 NZ_CP031843:727163-727444 [Bartonella kosoyi]
MRTIERTTIFKRDFKREMKGRYRHLLDTDLRKVIAALANDQPLELRYHDHALTGNWKDYRDCHIRPDLVLIYRLIGQERL
VLVRLGSHSQLNL

Nucleotide

• Length: 282 bp

>T110313 NZ_CP031843:727163-727444 [Bartonella kosoyi]
ATGCGGACGATTGAACGTACGACTATCTTCAAACGTGATTTCAAGCGTGAGATGAAAGGACGATATCGGCATCTTTTAGA
TACTGATTTACGCAAAGTCATCGCAGCATTAGCAAATGATCAACCTTTAGAGCTTCGATATCATGACCATGCTTTAACTG
GAAATTGGAAAGATTATCGGGATTGTCATATTCGACCTGATTTGGTTTTGATCTATCGCTTGATTGGTCAAGAGAGGCTC
GTTTTAGTGCGTCTTGGTTCTCATTCACAGCTTAATCTGTAA

Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 9640.88 Da
• Isoelectric Point: 4.1403

>AT110313 WP_100129267.1 NZ_CP031843:726913-727176 [Bartonella kosoyi]
MATSRMVQARVPEEIQNVANQVIQASGLSVSDVVRVLMTRIAQDKAIPSFLFQPNAETIAAFAELDEGNLKKFHSVDELF
DDLYADD

Nucleotide

• Length: 264 bp

>AT110313 NZ_CP031843:726913-727176 [Bartonella kosoyi]
ATGGCTACCAGTCGCATGGTTCAAGCACGTGTACCGGAAGAAATTCAAAATGTTGCTAATCAAGTTATTCAAGCCTCTGG
TTTGTCAGTAAGTGATGTCGTGAGAGTGTTGATGACACGTATTGCGCAAGATAAAGCTATTCCTTCTTTTTTGTTTCAAC
CCAATGCAGAAACCATAGCGGCTTTTGCTGAACTTGATGAAGGCAACTTAAAAAAGTTTCATTCCGTAGACGAATTATTT
GATGATCTCTATGCGGACGATTGA