Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 1917460..1917937 Replicon chromosome
Accession NZ_CP031839
Organism Staphylococcus aureus strain NX-T55

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag D1O27_RS10175 Protein ID WP_000052076.1
Coordinates 1917749..1917937 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag D1O27_RS10170 Protein ID WP_001059690.1
Coordinates 1917460..1917720 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D1O27_RS10135 1912852..1913568 - 717 WP_031589686.1 type I 3-dehydroquinate dehydratase -
D1O27_RS10140 1913716..1914138 + 423 WP_000974460.1 organic hydroperoxide resistance protein -
D1O27_RS10145 1914537..1915031 + 495 WP_000569884.1 GNAT family N-acetyltransferase -
D1O27_RS10150 1915187..1915804 + 618 WP_000255553.1 LysE/ArgO family amino acid transporter -
D1O27_RS10155 1915877..1916458 - 582 WP_001140697.1 phosphoglycerate mutase family protein -
D1O27_RS10160 1916683..1916919 + 237 WP_000368687.1 hypothetical protein -
D1O27_RS10165 1916916..1917119 - 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
D1O27_RS10170 1917460..1917720 + 261 WP_001059690.1 hypothetical protein Antitoxin
D1O27_RS10175 1917749..1917937 + 189 WP_000052076.1 hypothetical protein Toxin
D1O27_RS10180 1918125..1918694 + 570 WP_001106652.1 hypothetical protein -
D1O27_RS10185 1918782..1919066 + 285 WP_031590186.1 hypothetical protein -
D1O27_RS10190 1919128..1919346 + 219 WP_000005887.1 hypothetical protein -
D1O27_RS10195 1919842..1920042 - 201 WP_001059082.1 cold-shock protein -
D1O27_RS10200 1920399..1921085 - 687 WP_001641381.1 thermonuclease family protein -
D1O27_RS10205 1921426..1921902 - 477 WP_000824477.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-99)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-38)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T110305 WP_000052076.1 NZ_CP031839:1917749-1917937 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T110305 NZ_CP031839:1917749-1917937 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT110305 WP_001059690.1 NZ_CP031839:1917460-1917720 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT110305 NZ_CP031839:1917460-1917720 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTATATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References