Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 1979799..1980276 Replicon chromosome
Accession NZ_CP031838
Organism Staphylococcus aureus strain QD-CD9

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag D1G35_RS10410 Protein ID WP_000052076.1
Coordinates 1980088..1980276 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag D1G35_RS10405 Protein ID WP_001059690.1
Coordinates 1979799..1980059 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D1G35_RS10370 1975191..1975907 - 717 WP_031589686.1 type I 3-dehydroquinate dehydratase -
D1G35_RS10375 1976055..1976477 + 423 WP_000974460.1 organic hydroperoxide resistance protein -
D1G35_RS10380 1976876..1977370 + 495 WP_000569884.1 GNAT family N-acetyltransferase -
D1G35_RS10385 1977526..1978143 + 618 WP_000255553.1 LysE/ArgO family amino acid transporter -
D1G35_RS10390 1978216..1978797 - 582 WP_001140697.1 phosphoglycerate mutase family protein -
D1G35_RS10395 1979022..1979258 + 237 WP_000368687.1 hypothetical protein -
D1G35_RS10400 1979255..1979458 - 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
D1G35_RS10405 1979799..1980059 + 261 WP_001059690.1 hypothetical protein Antitoxin
D1G35_RS10410 1980088..1980276 + 189 WP_000052076.1 hypothetical protein Toxin
D1G35_RS10415 1980464..1981033 + 570 WP_001106652.1 hypothetical protein -
D1G35_RS10420 1981121..1981405 + 285 WP_031590186.1 hypothetical protein -
D1G35_RS10425 1981467..1981685 + 219 WP_000005887.1 hypothetical protein -
D1G35_RS10430 1982181..1982381 - 201 WP_001059082.1 cold-shock protein -
D1G35_RS10435 1982738..1983424 - 687 WP_001641381.1 thermonuclease family protein -
D1G35_RS10440 1983765..1984241 - 477 WP_000824477.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(6-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-72)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T110288 WP_000052076.1 NZ_CP031838:1980088-1980276 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T110288 NZ_CP031838:1980088-1980276 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT110288 WP_001059690.1 NZ_CP031838:1979799-1980059 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT110288 NZ_CP031838:1979799-1980059 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTATATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References