Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4259923..4260721 Replicon chromosome
Accession NZ_CP031833
Organism Escherichia coli strain 2452

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag D0R13_RS21935 Protein ID WP_000854907.1
Coordinates 4260344..4260721 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag D0R13_RS21930 Protein ID WP_047659145.1
Coordinates 4259923..4260297 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D0R13_RS21895 4255749..4256429 + 681 WP_001282919.1 WYL domain-containing protein -
D0R13_RS21900 4256577..4257254 + 678 WP_001097301.1 hypothetical protein -
D0R13_RS21905 4257284..4257493 + 210 WP_032150870.1 DUF905 family protein -
D0R13_RS21910 4257583..4258401 + 819 WP_117355316.1 DUF945 domain-containing protein -
D0R13_RS21915 4258493..4258978 + 486 WP_000213717.1 antirestriction protein -
D0R13_RS21920 4258994..4259470 + 477 WP_136676333.1 RadC family protein -
D0R13_RS21925 4259539..4259760 + 222 WP_001220316.1 DUF987 domain-containing protein -
D0R13_RS21930 4259923..4260297 + 375 WP_047659145.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
D0R13_RS21935 4260344..4260721 + 378 WP_000854907.1 TA system toxin CbtA family protein Toxin
D0R13_RS21940 4260718..4261206 + 489 WP_047659142.1 hypothetical protein -
D0R13_RS21945 4261226..4261423 + 198 WP_000772027.1 DUF957 domain-containing protein -
D0R13_RS21950 4261508..4262356 + 849 WP_024249539.1 DUF4942 domain-containing protein -
D0R13_RS21960 4262628..4263278 - 651 WP_000056760.1 3-keto-L-gulonate-6-phosphate decarboxylase UlaD -
D0R13_RS21965 4263292..4263756 - 465 WP_000776505.1 PTS ascorbate transporter subunit IIA -
D0R13_RS21970 4263766..4264071 - 306 WP_000218362.1 PTS ascorbate transporter subunit IIB -
D0R13_RS21975 4264087..4265484 - 1398 WP_001351893.1 PTS ascorbate transporter subunit IIC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 4248683..4274911 26228


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-116)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14050.02 Da        Isoelectric Point: 7.9086

>T110270 WP_000854907.1 NZ_CP031833:4260344-4260721 [Escherichia coli]
MKTLSDTHVREVSRCPSPVTIWQTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGTSSQLINSIDILRARRATGLMTRSNYRTVNNITLGKHPEAKQ

Download         Length: 378 bp

>T110270 NZ_CP031833:4260344-4260721 [Escherichia coli]
ATGAAAACATTATCCGACACACATGTACGGGAGGTATCTCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAT
CCGACTGCTGGACCAGCATTATGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCAGGAACTTCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCACGCCGGGCAACAGGTCTGATGACCCGCAG
CAACTACAGAACGGTAAATAACATTACCCTGGGGAAGCATCCGGAGGCGAAACAATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13736.58 Da        Isoelectric Point: 6.4757

>AT110270 WP_047659145.1 NZ_CP031833:4259923-4260297 [Escherichia coli]
VSDTLPGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPIPAPATTS

Download         Length: 375 bp

>AT110270 NZ_CP031833:4259923-4260297 [Escherichia coli]
GTGTCAGACACACTTCCCGGGATAACGCATCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGCGCCCGTCTGGTGCAGGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGCT
TCAGCGACGCAGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGACATCAGCATACCGTCACGCTGTATGCGAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGATACCGGCACCCGCAACCACCTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References