Detailed information of TA system TA110268

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX-GNAT
• Location: 4105439..4106253
• Replicon: chromosome
• Accession: NZ_CP031833
• Organism: Escherichia coli strain 2452

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: S1PA82
• Locus tag: D0R13_RS21130
• Protein ID: WP_001054376.1
• Coordinates: 4105439..4105696 (+)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: U9Z4B8
• Locus tag: D0R13_RS21135
• Protein ID: WP_001309181.1
• Coordinates: 4105708..4106253 (+)
• Length: 182 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D0R13_RS21100	4100727..4101833	+	1107	WP_001309184.1	N-acetylneuraminate epimerase	-
D0R13_RS21105	4101898..4102878	+	981	WP_000991438.1	9-O-acetyl-N-acetylneuraminic acid deacetylase	-
D0R13_RS21110	4103461..4104701	-	1241	Protein_3861	helicase YjhR	-
D0R13_RS21120	4104817..4105062	+	246	Protein_3862	GNAT family N-acetyltransferase	-
D0R13_RS21130	4105439..4105696	+	258	WP_001054376.1	hypothetical protein	Toxin
D0R13_RS21135	4105708..4106253	+	546	WP_001309181.1	N-acetyltransferase	Antitoxin
D0R13_RS21140	4106309..4107055	+	747	WP_000354251.1	class I SAM-dependent methyltransferase	-
D0R13_RS21145	4107224..4107442	+	219	Protein_3866	hypothetical protein	-
D0R13_RS25110	4107480..4107596	+	117	Protein_3867	VOC family protein	-
D0R13_RS21150	4107841..4108962	+	1122	WP_000010829.1	M42 family metallopeptidase	-
D0R13_RS21155	4108959..4109237	+	279	WP_000722973.1	PTS sugar transporter subunit IIB	-
D0R13_RS21160	4109249..4110562	+	1314	WP_000460843.1	galactitol-specific PTS transporter subunit IIC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	fimI / fimA / fimE / fimB	4095224..4135888	40664

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (18-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9734.29 Da
• Isoelectric Point: 11.0090

>T110268 WP_001054376.1 NZ_CP031833:4105439-4105696 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Nucleotide

• Length: 258 bp

>T110268 NZ_CP031833:4105439-4105696 [Escherichia coli]
ATGAATTTATCCCGTCAGGAACAACATACCTTACACGTTCTCGCTAAAGGTAGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGCCAGCCCTATCGAATCAACACCACCGAGCTGAATAAAGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin

Protein

• Length: 182 a.a.
• Molecular weight: 19956.90 Da
• Isoelectric Point: 6.3277

>AT110268 WP_001309181.1 NZ_CP031833:4105708-4106253 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Nucleotide

• Length: 546 bp

>AT110268 NZ_CP031833:4105708-4106253 [Escherichia coli]
ATGACAGTACACCACTTCACTTTTCATATCACAGATAAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAGTGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCCGCGTTATCGCTGCTAGCCC
GGTATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGAGAAATGGATTCACCGTTGATGCAC
ATCCTCGCTCCCCTGGCGGTCATACCGGAATACCAAGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAATCACTCACCGCT
CAGCCCATGACCCTGACCGGCCACATCCGGTGCGCAGACCCTGATGAAACCGGAGCACTGACGTGA

Structures

Toxin

• AlphaFold DB: S1PA82

Antitoxin

• AlphaFold DB: U9Z4B8