Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2812645..2813480 Replicon chromosome
Accession NZ_CP031833
Organism Escherichia coli strain 2452

Toxin (Protein)


Gene name yeeV Uniprot ID A0A6H2GFM1
Locus tag D0R13_RS14520 Protein ID WP_065304416.1
Coordinates 2812645..2813022 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A6H2GGB7
Locus tag D0R13_RS14525 Protein ID WP_001285390.1
Coordinates 2813112..2813480 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D0R13_RS14480 2807915..2808406 - 492 WP_001300785.1 DUF1097 domain-containing protein -
D0R13_RS14485 2808508..2809062 - 555 WP_001001921.1 molecular chaperone YcdY -
D0R13_RS14490 2809086..2809823 - 738 WP_000283667.1 zinc-binding phosphatase -
D0R13_RS14495 2809878..2810816 - 939 WP_000351317.1 glyoxylate/hydroxypyruvate reductase GhrA -
D0R13_RS14505 2811287..2812129 - 843 WP_065304417.1 DUF4942 domain-containing protein -
D0R13_RS14510 2812226..2812423 - 198 WP_086598277.1 DUF957 domain-containing protein -
D0R13_RS14515 2812469..2812648 - 180 Protein_2661 hypothetical protein -
D0R13_RS14520 2812645..2813022 - 378 WP_065304416.1 type IV toxin-antitoxin system toxin CbtA Toxin
D0R13_RS14525 2813112..2813480 - 369 WP_001285390.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
D0R13_RS14530 2813530..2814174 - 645 WP_065304415.1 antitoxin of toxin-antitoxin stability system -
D0R13_RS14535 2814189..2814410 - 222 WP_000692312.1 DUF987 domain-containing protein -
D0R13_RS14540 2814479..2814955 - 477 WP_001186747.1 RadC family protein -
D0R13_RS14545 2814970..2815455 - 486 WP_000214317.1 antirestriction protein -
D0R13_RS14550 2815546..2816367 - 822 WP_106668205.1 DUF945 domain-containing protein -
D0R13_RS14560 2816588..2816998 - 411 WP_000846713.1 hypothetical protein -
D0R13_RS14565 2817014..2817691 - 678 WP_059239983.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - csgB / csgD / csgE / csgF / csgG 2804294..2835146 30852


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14060.06 Da        Isoelectric Point: 7.8522

>T110264 WP_065304416.1 NZ_CP031833:c2813022-2812645 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYQEAKQ

Download         Length: 378 bp

>T110264 NZ_CP031833:c2813022-2812645 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCACGCCCGTCTCCGGTTGAAATCTGGCAGACACTGCTCAC
CCGACTGCTGGATCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGCGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCACGCCGGGCAACCGGCCTGATGACACGCGA
CAACTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCAGGAGGCGAAACAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13811.52 Da        Isoelectric Point: 5.9618

>AT110264 WP_001285390.1 NZ_CP031833:c2813480-2813112 [Escherichia coli]
VSDTFHETNYPDDNNDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADSYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYMAVYPTPETKK

Download         Length: 369 bp

>AT110264 NZ_CP031833:c2813480-2813112 [Escherichia coli]
GTGTCAGACACGTTCCATGAAACAAATTATCCCGACGACAACAACGACCGCCCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTTGGTGCCCGTCTGGTACAGGAAGGCAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGGCGGT
TCAGCGACGCGGATTCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAGCTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAACATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGATACCCTCGGCAGTTG
TGGCTACGTTTATATGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6H2GFM1

Antitoxin

Source ID Structure
AlphaFold DB A0A6H2GGB7

References