110243

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 181029..181555 Replicon plasmid unnamed1
Accession NZ_CP031818
Organism Klebsiella pneumoniae strain INF235-sc-2280127

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag D0898_RS26545 Protein ID WP_000323025.1
Coordinates 181029..181316 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag D0898_RS26550 Protein ID WP_000534858.1
Coordinates 181316..181555 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D0898_RS26525 177542..177919 + 378 WP_045289277.1 hypothetical protein -
D0898_RS29165 178117..179091 - 975 WP_174232731.1 Hok/Gef family protein -
D0898_RS26535 179698..179856 - 159 WP_004181898.1 type I toxin-antitoxin system Hok family toxin -
D0898_RS26540 179928..180962 + 1035 Protein_176 IS481 family transposase -
D0898_RS26545 181029..181316 - 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
D0898_RS26550 181316..181555 - 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
D0898_RS26555 181952..182968 + 1017 WP_001310555.1 IS5-like element IS5 family transposase -
D0898_RS26560 183345..184082 - 738 WP_004201234.1 hypothetical protein -
D0898_RS26565 184220..184906 - 687 WP_004201232.1 NYN domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - pla 1..430829 430829
- inside IScluster/Tn - - 179928..182968 3040


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T110243 WP_000323025.1 NZ_CP031818:c181316-181029 [Klebsiella pneumoniae]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T110243 NZ_CP031818:c181316-181029 [Klebsiella pneumoniae]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT110243 WP_000534858.1 NZ_CP031818:c181555-181316 [Klebsiella pneumoniae]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp

>AT110243 NZ_CP031818:c181555-181316 [Klebsiella pneumoniae]
ATGGGTAGCATTAACCTACGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGCGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGACTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
AlphaFold DB A0A4V1CTS8

References