Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yfjZ/CbtA-CbeA
Location 4509030..4509721 Replicon chromosome
Accession NZ_CP031817
Organism Klebsiella pneumoniae strain INF235-sc-2280127

Toxin (Protein)


Gene name ykfI Uniprot ID -
Locus tag D0898_RS22380 Protein ID WP_064161707.1
Coordinates 4509030..4509371 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID -
Locus tag D0898_RS22385 Protein ID WP_009309815.1
Coordinates 4509395..4509721 (-) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D0898_RS22355 4504661..4505182 - 522 Protein_4285 TetR family transcriptional regulator -
D0898_RS22360 4505407..4506387 + 981 WP_009309820.1 adenosine deaminase -
D0898_RS22365 4506384..4506938 + 555 WP_009309819.1 hypothetical protein -
D0898_RS22370 4506938..4507732 + 795 WP_064161706.1 SIR2 family protein -
D0898_RS22375 4508080..4508913 - 834 WP_009309817.1 DUF4942 domain-containing protein -
D0898_RS22380 4509030..4509371 - 342 WP_064161707.1 TA system toxin CbtA family protein Toxin
D0898_RS22385 4509395..4509721 - 327 WP_009309815.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
D0898_RS22390 4509735..4510211 - 477 WP_048982609.1 DNA repair protein RadC -
D0898_RS22395 4510222..4510668 - 447 WP_009309813.1 antirestriction protein -
D0898_RS22400 4510879..4511568 - 690 WP_009309812.1 hypothetical protein -
D0898_RS22410 4512133..4513023 - 891 WP_064161708.1 50S ribosome-binding GTPase -
D0898_RS22415 4513106..4514194 - 1089 WP_064161709.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4484411..4529551 45140


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-109)

Antitoxin

Antitoxin CbeA

(8-107)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12932.90 Da        Isoelectric Point: 8.4982

>T110239 WP_064161707.1 NZ_CP031817:c4509371-4509030 [Klebsiella pneumoniae]
MKTLPATTQRAAKPCPSPMTVWQMLLTRLLEQHYGLSLNDTPFSDETVIQEHINAGITLADAVNFLVEKYELVRIDRRGF
NCQEQSPYLRAVDILRARQATGLLQYRRNTLSL

Download         Length: 342 bp

>T110239 NZ_CP031817:c4509371-4509030 [Klebsiella pneumoniae]
ATGAAAACCTTACCTGCAACAACTCAGCGGGCGGCTAAGCCGTGCCCGTCTCCCATGACAGTCTGGCAGATGCTACTTAC
CCGTCTGCTGGAGCAACATTATGGCCTTTCTCTGAATGACACGCCGTTCAGCGATGAAACCGTTATTCAGGAACATATCA
ACGCCGGTATTACGCTGGCTGATGCTGTTAACTTTCTGGTGGAAAAGTACGAACTGGTACGTATCGATCGCAGAGGGTTT
AACTGTCAGGAACAGTCACCTTATCTACGGGCGGTAGATATTTTACGGGCTCGGCAGGCAACCGGTCTGCTGCAATATCG
TCGTAACACCTTGTCGCTCTAA

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 12292.01 Da        Isoelectric Point: 6.6290

>AT110239 WP_009309815.1 NZ_CP031817:c4509721-4509395 [Klebsiella pneumoniae]
MPLTDAIQWGLKRSFTPNFGARLVQEGNRLHYLADRANITGKFVDVECQKLEEAFPHFIRQMELMLSTGELNPRHAHSVT
LYHNAFTCEADTLGSCGYVYIVIYPTQS

Download         Length: 327 bp

>AT110239 NZ_CP031817:c4509721-4509395 [Klebsiella pneumoniae]
ATGCCACTGACTGATGCCATACAGTGGGGATTAAAGCGAAGTTTCACACCGAATTTTGGCGCAAGGCTGGTACAGGAAGG
CAACCGACTGCACTACCTGGCTGACCGGGCCAATATCACCGGTAAGTTTGTTGATGTTGAATGTCAGAAGCTGGAAGAAG
CATTCCCGCATTTTATCCGCCAGATGGAACTGATGCTGAGCACTGGCGAACTTAATCCCCGTCATGCGCACAGCGTCACT
CTCTACCACAACGCTTTCACCTGTGAAGCCGATACTCTCGGTAGTTGTGGTTACGTCTACATCGTTATTTATCCCACTCA
AAGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References