Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 808188..808845 Replicon chromosome
Accession NZ_CP031817
Organism Klebsiella pneumoniae strain INF235-sc-2280127

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag D0898_RS04125 Protein ID WP_002916310.1
Coordinates 808435..808845 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag D0898_RS04120 Protein ID WP_002916312.1
Coordinates 808188..808454 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D0898_RS04095 803344..804777 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
D0898_RS04100 804896..805624 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
D0898_RS04105 805674..805985 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
D0898_RS04110 806149..806808 + 660 WP_002916317.1 hemolysin III family protein -
D0898_RS04115 806959..807942 - 984 WP_009308615.1 tRNA-modifying protein YgfZ -
D0898_RS04120 808188..808454 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
D0898_RS04125 808435..808845 + 411 WP_002916310.1 protein YgfX Toxin
D0898_RS04130 808852..809373 - 522 WP_004144730.1 flavodoxin FldB -
D0898_RS04135 809474..810370 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
D0898_RS04140 810393..811106 + 714 WP_004185548.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
D0898_RS04145 811112..812845 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T110226 WP_002916310.1 NZ_CP031817:808435-808845 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T110226 NZ_CP031817:808435-808845 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT110226 WP_002916312.1 NZ_CP031817:808188-808454 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT110226 NZ_CP031817:808188-808454 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References