Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yfjZ/CbtA-CbeA
Location 659386..660089 Replicon chromosome
Accession NZ_CP031817
Organism Klebsiella pneumoniae strain INF235-sc-2280127

Toxin (Protein)


Gene name ykfI Uniprot ID -
Locus tag D0898_RS03350 Protein ID WP_009309675.1
Coordinates 659748..660089 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID -
Locus tag D0898_RS03345 Protein ID WP_009309674.1
Coordinates 659386..659727 (+) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D0898_RS03320 654902..656064 + 1163 WP_087728260.1 IS3 family transposase -
D0898_RS03325 656456..657328 + 873 WP_196983271.1 hypothetical protein -
D0898_RS03330 657526..658347 + 822 WP_009309670.1 DUF945 domain-containing protein -
D0898_RS03335 658378..658820 + 443 Protein_633 antirestriction protein -
D0898_RS03340 658833..659375 + 543 WP_009309673.1 DNA repair protein RadC -
D0898_RS03345 659386..659727 + 342 WP_009309674.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
D0898_RS03350 659748..660089 + 342 WP_009309675.1 TA system toxin CbtA family protein Toxin
D0898_RS03360 660451..660957 + 507 WP_002917636.1 G/U mismatch-specific DNA glycosylase -
D0898_RS03365 661057..662898 - 1842 WP_004174339.1 RNA polymerase sigma factor RpoD -
D0898_RS03370 663117..664862 - 1746 WP_004149864.1 DNA primase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(13-112)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12822.76 Da        Isoelectric Point: 9.6542

>T110224 WP_009309675.1 NZ_CP031817:659748-660089 [Klebsiella pneumoniae]
MKTLPATISRAAKPCLSPVAAWQMLLTRLLEQHYGLTLNDTPFSDETVIKEHIDAEITLADAVNFLVDKYGLVRIDRRGF
NWQEQSPYLRAVDILRARQATGLLRRSRNNAVS

Download         Length: 342 bp

>T110224 NZ_CP031817:659748-660089 [Klebsiella pneumoniae]
ATGAAAACTCTACCTGCTACAATTTCGCGTGCGGCGAAGCCCTGTCTGTCGCCCGTTGCAGCCTGGCAAATGTTACTGAC
ACGCCTACTGGAACAGCACTATGGCCTGACACTGAACGACACGCCGTTCAGTGATGAAACAGTTATTAAGGAACATATTG
ATGCCGAGATTACCCTGGCTGATGCAGTCAACTTCTTGGTGGATAAGTACGGACTGGTTCGTATCGATCGCAGGGGGTTT
AACTGGCAGGAACAATCGCCTTATCTTCGGGCTGTAGATATTCTGCGAGCACGACAGGCAACTGGCTTGCTGCGACGGAG
CCGTAATAATGCTGTATCGTGA

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12735.41 Da        Isoelectric Point: 6.3157

>AT110224 WP_009309674.1 NZ_CP031817:659386-659727 [Klebsiella pneumoniae]
MKSTESENDLFLKWGLNRNVTPCFGARLVQEGNRLHYLADRASITGAFSNAESLKLDEVFPRFISQMESMLTIGEMNPHH
AHCVTLYHNGFTCEADTLGSCGYVYIAVYPTQR

Download         Length: 342 bp

>AT110224 NZ_CP031817:659386-659727 [Klebsiella pneumoniae]
ATGAAATCTACTGAGTCAGAGAACGATTTATTTCTCAAGTGGGGTCTGAATCGTAATGTGACACCTTGCTTTGGCGCTCG
TCTGGTACAGGAGGGAAACCGACTTCACTATCTGGCTGACCGGGCCAGCATTACCGGTGCATTCAGTAACGCAGAATCTT
TGAAGTTGGATGAAGTATTCCCACGTTTTATCAGCCAGATGGAATCGATGTTGACCATTGGTGAAATGAATCCTCACCAT
GCCCACTGCGTCACCCTATACCACAACGGTTTCACCTGCGAAGCCGATACTCTTGGCAGTTGCGGCTACGTATACATCGC
CGTTTACCCCACTCAACGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References