Detailed information of TA system TA110218

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 4720374..4720890
• Replicon: chromosome
• Accession: NZ_CP031814
• Organism: Klebsiella pneumoniae strain KSB1_7F-sc-2280268

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: D0899_RS23785
• Protein ID: WP_117082801.1
• Coordinates: 4720374..4720658 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: R4Y888
• Locus tag: D0899_RS23790
• Protein ID: WP_002886901.1
• Coordinates: 4720648..4720890 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D0899_RS23765	4715844..4716152	-	309	WP_016947038.1	PTS sugar transporter subunit IIB	-
D0899_RS28205	4716237..4716410	+	174	WP_002886906.1	hypothetical protein	-
D0899_RS23770	4716413..4717156	+	744	WP_002886905.1	MurR/RpiR family transcriptional regulator	-
D0899_RS23775	4717513..4719651	+	2139	WP_004186701.1	anaerobic ribonucleoside-triphosphate reductase	-
D0899_RS23780	4719906..4720370	+	465	WP_004178375.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
D0899_RS23785	4720374..4720658	-	285	WP_117082801.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
D0899_RS23790	4720648..4720890	-	243	WP_002886901.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
D0899_RS23795	4720968..4722878	-	1911	WP_009486549.1	BglG family transcription antiterminator	-
D0899_RS23800	4722901..4724055	-	1155	WP_002886900.1	lactonase family protein	-
D0899_RS23805	4724122..4724862	-	741	WP_002886899.1	KDGP aldolase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-82)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-80)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 11139.98 Da
• Isoelectric Point: 10.4951

>T110218 WP_117082801.1 NZ_CP031814:c4720658-4720374 [Klebsiella pneumoniae]
MTYELEFDPRARREWQKPGETIKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Nucleotide

• Length: 285 bp

>T110218 NZ_CP031814:c4720658-4720374 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCAGGCGCGAATGGCAGAAGCCTGGCGAGACGATCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9045.55 Da
• Isoelectric Point: 6.3340

>AT110218 WP_002886901.1 NZ_CP031814:c4720890-4720648 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Nucleotide

• Length: 243 bp

>AT110218 NZ_CP031814:c4720890-4720648 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCAGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Structures

Antitoxin

• AlphaFold DB: A0A0H3GLP0