Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 3577079..3577595 Replicon chromosome
Accession NZ_CP031800
Organism Klebsiella pneumoniae strain MSB1_8A-sc-2280397

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag D0887_RS17995 Protein ID WP_040216106.1
Coordinates 3577079..3577363 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag D0887_RS18000 Protein ID WP_064162488.1
Coordinates 3577353..3577595 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D0887_RS17975 3572496..3572804 - 309 WP_012737232.1 PTS sugar transporter subunit IIB -
D0887_RS32210 3572889..3573062 + 174 WP_032425422.1 hypothetical protein -
D0887_RS17980 3573065..3573808 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
D0887_RS17985 3574165..3576303 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
D0887_RS17990 3576611..3577075 + 465 WP_064162487.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
D0887_RS17995 3577079..3577363 - 285 WP_040216106.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
D0887_RS18000 3577353..3577595 - 243 WP_064162488.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
D0887_RS18005 3577673..3579583 - 1911 WP_023325426.1 BglG family transcription antiterminator -
D0887_RS18010 3579606..3580760 - 1155 WP_064162489.1 lactonase family protein -
D0887_RS18015 3580827..3581567 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(7-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-69)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11097.94 Da        Isoelectric Point: 10.4962

>T110169 WP_040216106.1 NZ_CP031800:c3577363-3577079 [Klebsiella pneumoniae]
MTYELAFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T110169 NZ_CP031800:c3577363-3577079 [Klebsiella pneumoniae]
ATGACCTATGAACTGGCGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9059.57 Da        Isoelectric Point: 6.3340

>AT110169 WP_064162488.1 NZ_CP031800:c3577595-3577353 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPLKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT110169 NZ_CP031800:c3577595-3577353 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGTTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References