Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/ElaA-DUF1778
Location 28663..29402 Replicon plasmid unnamed1
Accession NZ_CP031796
Organism Klebsiella pneumoniae strain INF125-sc-2279943

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag D0884_RS26510 Protein ID WP_117389532.1
Coordinates 28917..29402 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID -
Locus tag D0884_RS26505 Protein ID WP_049095044.1
Coordinates 28663..28929 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D0884_RS28445 23933..24620 + 688 Protein_30 DUF4113 domain-containing protein -
D0884_RS26480 24742..25185 + 444 WP_004026357.1 DUF2384 domain-containing protein -
D0884_RS26485 25182..25652 + 471 WP_048984280.1 RES family NAD+ phosphorylase -
D0884_RS26490 25763..26023 - 261 WP_004026352.1 hypothetical protein -
D0884_RS26495 26532..27901 + 1370 WP_087661561.1 IS3 family transposase -
D0884_RS26500 28102..28530 + 429 WP_004901287.1 GFA family protein -
D0884_RS26505 28663..28929 + 267 WP_049095044.1 DUF1778 domain-containing protein Antitoxin
D0884_RS26510 28917..29402 + 486 WP_117389532.1 GNAT family N-acetyltransferase Toxin
D0884_RS26515 29821..31161 + 1341 WP_049095043.1 ISNCY family transposase -
D0884_RS26525 31594..31767 - 174 WP_176240559.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - pla 1..169772 169772
- inside IScluster/Tn - - 27176..31767 4591


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(45-149)

Antitoxin

Vibrio phage ICP1, Orf50

(2-87)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17668.49 Da        Isoelectric Point: 10.3370

>T110138 WP_117389532.1 NZ_CP031796:28917-29402 [Klebsiella pneumoniae]
VGRITAPEPLFSAHQLAEFVSGETVLDEWLKQRGLKNQALGAARTFVVCKKGTKQVAGFYSLATGSVNHTEATGSLRRNM
PDPIPVIILARLAVDVSLRGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKPSQTQPRTLFLRLP
Q

Download         Length: 486 bp

>T110138 NZ_CP031796:28917-29402 [Klebsiella pneumoniae]
GTGGGACGTATAACCGCGCCCGAACCGTTATTCAGCGCTCATCAGCTGGCTGAGTTCGTCAGTGGAGAGACAGTCCTCGA
TGAATGGCTAAAACAGAGAGGTTTAAAAAATCAAGCTCTTGGCGCTGCCCGAACGTTCGTTGTTTGCAAGAAGGGTACGA
AGCAAGTAGCTGGTTTTTACTCTTTGGCCACCGGTAGCGTTAACCATACGGAAGCGACAGGCAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTCTCATTGCGCGGAAAAGGGCTTGGCGCTGATTT
ACTTCATGATGCAGTACTTCGTTGCTATCGGGTTGCCGAGAATATAGGTGTACGTGCAATCATGGTTCATGCGCTCACAG
AAGAAGCCAAAAATTTCTACATTCACCATGGTTTCAAACCATCACAAACTCAGCCGCGGACACTGTTCCTCAGACTCCCT
CAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10163.63 Da        Isoelectric Point: 4.5256

>AT110138 WP_049095044.1 NZ_CP031796:28663-28929 [Klebsiella pneumoniae]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACKAAENVILDRRVFNFNDEQYAEFIDMLDAPVEDELAINKLL
ARKPQWDV

Download         Length: 267 bp

>AT110138 NZ_CP031796:28663-28929 [Klebsiella pneumoniae]
ATGAAATCAGATGTTCAGCTCAACCTAAGAGCTAAAGAGTCTCAGAGAGCACTCATCGATGCCGCTGCAGAGATCCTTCA
TAAATCGCGAACCGACTTTATCCTGGAGATGGCCTGCAAGGCTGCGGAGAATGTGATCCTTGATCGCCGTGTTTTCAATT
TTAACGACGAACAGTATGCAGAGTTCATCGATATGCTCGATGCACCAGTCGAGGATGAGCTCGCCATTAATAAACTACTG
GCAAGGAAACCTCAGTGGGACGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References