Detailed information of TA system TA110137

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /RES-TIGR02293
• Location: 24742..25652
• Replicon: plasmid unnamed1
• Accession: NZ_CP031796
• Organism: Klebsiella pneumoniae strain INF125-sc-2279943

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: D0884_RS26485
• Protein ID: WP_048984280.1
• Coordinates: 25182..25652 (+)
• Length: 157 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: A0A6P1V3Q9
• Locus tag: D0884_RS26480
• Protein ID: WP_004026357.1
• Coordinates: 24742..25185 (+)
• Length: 148 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D0884_RS26450	20525..20863	-	339	WP_049095046.1	hypothetical protein	-
D0884_RS26455	21062..21784	+	723	Protein_27	DUF969 domain-containing protein	-
D0884_RS26460	21781..22767	+	987	Protein_28	DUF979 domain-containing protein	-
D0884_RS26465	22777..23772	+	996	WP_049095045.1	DUF2891 domain-containing protein	-
D0884_RS28445	23933..24620	+	688	Protein_30	DUF4113 domain-containing protein	-
D0884_RS26480	24742..25185	+	444	WP_004026357.1	DUF2384 domain-containing protein	Antitoxin
D0884_RS26485	25182..25652	+	471	WP_048984280.1	RES family NAD+ phosphorylase	Toxin
D0884_RS26490	25763..26023	-	261	WP_004026352.1	hypothetical protein	-
D0884_RS26495	26532..27901	+	1370	WP_087661561.1	IS3 family transposase	-
D0884_RS26500	28102..28530	+	429	WP_004901287.1	GFA family protein	-
D0884_RS26505	28663..28929	+	267	WP_049095044.1	DUF1778 domain-containing protein	-
D0884_RS26510	28917..29402	+	486	WP_117389532.1	GNAT family N-acetyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	pla	1..169772	169772
	-	inside	IScluster/Tn	-	-	27176..31767	4591

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (3-148)

Antitoxin

• Antitoxin Xre-like, helix-turn-helix domain (30-89)

Sequences

Toxin

Protein

• Length: 157 a.a.
• Molecular weight: 17524.80 Da
• Isoelectric Point: 4.7599

>T110137 WP_048984280.1 NZ_CP031796:25182-25652 [Klebsiella pneumoniae]
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQHIPFRFDSRLKPDRK

Nucleotide

• Length: 471 bp

>T110137 NZ_CP031796:25182-25652 [Klebsiella pneumoniae]
GTGATCCTCTACAGGCTGACGAAAACAAAGTATCTTTCTACGGCCTGGACCGGATATGGTGCGAAAGAGGCTGGTGGGCG
CTGGAATAGCGTGGGGGTGTCAATGGTATATGTCTCCGAAACGGCATCACTAACGATGCTGGAAACGTTGGTACACCTGC
ATGCGGCACAGATAATGGACTCTTTCACTCTACTGAGTATCGATGTGCCTGATGAACTGATCCAAAGCGCAAACATGGAT
GAATTACCGGGCAACTGGGCTGATGAGGATGCGCCACAGGAACTGGCTGATTACGGAGATGCCTGGTCATTTACCAGGAG
CTCGGTTGCACTGCGTGTTCCCTCAGCCTTATCGCCGGTAGAGTTCAATTATCTGTTAAATCCTGAGCACCCTGAGTTTT
ACGGGATCGTGCAGAAGGCTCAACACATACCGTTCCGGTTTGATAGTCGTCTTAAACCTGACAGGAAGTGA

Antitoxin

Protein

• Length: 148 a.a.
• Molecular weight: 16480.80 Da
• Isoelectric Point: 10.2498

>AT110137 WP_004026357.1 NZ_CP031796:24742-25185 [Klebsiella pneumoniae]
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVANRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDKEAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS

Nucleotide

• Length: 444 bp

>AT110137 NZ_CP031796:24742-25185 [Klebsiella pneumoniae]
ATGAAAACATTTAGTTTGTCCTCAACTCCAGCCAGACCACAGCGCCTCTGGCAGGTTGCCGGGTTAAATAATGCTGATGG
CGTAGCGCTGCTGGGTCAAATCAATGAAGGCCTGGACGGGAAGGTGGCGAACCGGATCACTGACTGGGCCAGAATAACCC
AAAATGACCTGAGAAAAATGTCCGGTATCCCGTCGACCACATTTAGCCGCAGTGTGAAGGCACGTTTTAACCCGGAACAA
AGTGAACGACTGGTACGTATTATCCGCGTCATTGATCGGGCGGTAGATTTGTTTGAAGGCGACAAGGAAGCCGCACAGAA
GTGGTTGAACGAACCTAACCGGGCATTGAGCTGGAAAGTGCCAGCAGACCTGATGGCATCCGAGACAGGAGCGTATGAGG
TCATTAAGCTGATTACGCGTCTGGAGCATGGGGTGTACTCGTGA

Structures

Antitoxin

• AlphaFold DB: A0A6P1V3Q9