Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 807904..808561 Replicon chromosome
Accession NZ_CP031795
Organism Klebsiella pneumoniae strain INF125-sc-2279943

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag D0884_RS04105 Protein ID WP_002916310.1
Coordinates 808151..808561 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag D0884_RS04100 Protein ID WP_002916312.1
Coordinates 807904..808170 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D0884_RS04075 803060..804493 - 1434 WP_009485881.1 6-phospho-beta-glucosidase BglA -
D0884_RS04080 804612..805340 - 729 WP_009485882.1 MurR/RpiR family transcriptional regulator -
D0884_RS04085 805390..805701 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
D0884_RS04090 805865..806524 + 660 WP_002916317.1 hemolysin III family protein -
D0884_RS04095 806675..807658 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
D0884_RS04100 807904..808170 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
D0884_RS04105 808151..808561 + 411 WP_002916310.1 protein YgfX Toxin
D0884_RS04110 808568..809089 - 522 WP_002916308.1 flavodoxin FldB -
D0884_RS04115 809190..810086 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
D0884_RS04120 810109..810822 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
D0884_RS04125 810828..812561 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T110122 WP_002916310.1 NZ_CP031795:808151-808561 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T110122 NZ_CP031795:808151-808561 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT110122 WP_002916312.1 NZ_CP031795:807904-808170 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT110122 NZ_CP031795:807904-808170 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References