Detailed information of TA system TA110116

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 4711011..4711527
• Replicon: chromosome
• Accession: NZ_CP031792
• Organism: Klebsiella pneumoniae strain INF116-sc-2279924

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: D0883_RS23400
• Protein ID: WP_117380908.1
• Coordinates: 4711011..4711295 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: R4Y888
• Locus tag: D0883_RS23405
• Protein ID: WP_002886901.1
• Coordinates: 4711285..4711527 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D0883_RS23380	4706407..4706715	-	309	WP_002886907.1	PTS sugar transporter subunit IIB	-
D0883_RS28330	4706800..4706973	+	174	WP_004222159.1	hypothetical protein	-
D0883_RS23385	4706976..4707719	+	744	WP_002886905.1	MurR/RpiR family transcriptional regulator	-
D0883_RS23390	4708076..4710214	+	2139	WP_004186701.1	anaerobic ribonucleoside-triphosphate reductase	-
D0883_RS23395	4710543..4711007	+	465	WP_002886903.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
D0883_RS23400	4711011..4711295	-	285	WP_117380908.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
D0883_RS23405	4711285..4711527	-	243	WP_002886901.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
D0883_RS23410	4711605..4713515	-	1911	WP_117380909.1	BglG family transcription antiterminator	-
D0883_RS23415	4713538..4714692	-	1155	WP_004178372.1	lactonase family protein	-
D0883_RS23420	4714759..4715499	-	741	WP_002886899.1	KDGP aldolase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-83)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-80)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 11072.90 Da
• Isoelectric Point: 10.2577

>T110116 WP_117380908.1 NZ_CP031792:c4711295-4711011 [Klebsiella pneumoniae]
MTYELEFDPRARCEWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Nucleotide

• Length: 285 bp

>T110116 NZ_CP031792:c4711295-4711011 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCAGGTGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9045.55 Da
• Isoelectric Point: 6.3340

>AT110116 WP_002886901.1 NZ_CP031792:c4711527-4711285 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Nucleotide

• Length: 243 bp

>AT110116 NZ_CP031792:c4711527-4711285 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCAGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Structures

Antitoxin

• AlphaFold DB: A0A0H3GLP0