Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4002046..4002665 Replicon chromosome
Accession NZ_CP031792
Organism Klebsiella pneumoniae strain INF116-sc-2279924

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag D0883_RS19885 Protein ID WP_002892050.1
Coordinates 4002447..4002665 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag D0883_RS19880 Protein ID WP_002892066.1
Coordinates 4002046..4002420 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D0883_RS19870 3997198..3998391 + 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
D0883_RS19875 3998414..4001560 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
D0883_RS19880 4002046..4002420 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
D0883_RS19885 4002447..4002665 + 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
D0883_RS19890 4002824..4003390 + 567 WP_002892030.1 maltose O-acetyltransferase -
D0883_RS28200 4003362..4003502 - 141 WP_004147370.1 hypothetical protein -
D0883_RS19895 4003523..4003993 + 471 WP_002892026.1 YlaC family protein -
D0883_RS19900 4003968..4005419 - 1452 WP_117380880.1 PLP-dependent aminotransferase family protein -
D0883_RS19905 4005520..4006218 + 699 WP_004177238.1 GNAT family N-acetyltransferase -
D0883_RS19910 4006215..4006355 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
D0883_RS19915 4006355..4006618 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T110114 WP_002892050.1 NZ_CP031792:4002447-4002665 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T110114 NZ_CP031792:4002447-4002665 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACCTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT110114 WP_002892066.1 NZ_CP031792:4002046-4002420 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT110114 NZ_CP031792:4002046-4002420 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References