Detailed information of TA system TA110103

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yfjZ-ypjF/CbtA-CbeA
• Location: 1170983..1171650
• Replicon: chromosome
• Accession: NZ_CP031792
• Organism: Klebsiella pneumoniae strain INF116-sc-2279924

Toxin (Protein)

• Gene name: ypjF
• Uniprot ID: -
• Locus tag: D0883_RS05990
• Protein ID: WP_047358936.1
• Coordinates: 1170983..1171312 (-)
• Length: 110 a.a.

Antitoxin (Protein)

• Gene name: yfjZ
• Uniprot ID: -
• Locus tag: D0883_RS05995
• Protein ID: WP_047358935.1
• Coordinates: 1171333..1171650 (-)
• Length: 106 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D0883_RS05965	1166024..1167199	-	1176	WP_020803752.1	multidrug efflux RND transporter periplasmic adaptor subunit OqxA	-
D0883_RS05970	1167533..1167895	+	363	WP_085783913.1	helix-turn-helix domain-containing protein	-
D0883_RS05975	1167906..1168478	-	573	WP_004212922.1	flavin reductase	-
D0883_RS05980	1168690..1169574	+	885	WP_020803747.1	LysR family transcriptional regulator	-
D0883_RS05985	1169699..1170499	+	801	WP_004180956.1	hypothetical protein	-
D0883_RS05990	1170983..1171312	-	330	WP_047358936.1	TA system toxin CbtA family protein	Toxin
D0883_RS05995	1171333..1171650	-	318	WP_047358935.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
D0883_RS06000	1171669..1171890	-	222	WP_047358934.1	DUF987 domain-containing protein	-
D0883_RS06005	1171899..1172381	-	483	WP_032238502.1	DNA repair protein RadC	-
D0883_RS06010	1172390..1172842	-	453	WP_117380721.1	antirestriction protein	-
D0883_RS06015	1172928..1173164	-	237	WP_047358932.1	DUF905 domain-containing protein	-
D0883_RS06020	1173242..1173652	-	411	WP_047358931.1	hypothetical protein	-
D0883_RS06025	1173717..1174154	-	438	WP_038434461.1	hypothetical protein	-
D0883_RS06030	1174196..1174732	-	537	WP_047358930.1	DUF4339 domain-containing protein	-
D0883_RS06035	1174758..1175468	-	711	WP_047358929.1	DeoR family transcriptional regulator	-
D0883_RS06040	1175677..1176501	-	825	WP_047358928.1	DUF945 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-108)

Antitoxin

• Antitoxin CbeA (5-104)

Sequences

Toxin

Protein

• Length: 110 a.a.
• Molecular weight: 12344.43 Da
• Isoelectric Point: 9.5732

>T110103 WP_047358936.1 NZ_CP031792:c1171312-1170983 [Klebsiella pneumoniae]
MKTLPATISRAAKPCLSPVAVWQMLLTRLLEQHYGLMLSDTPFSDETVIKEHIDAGITLANAVNFLVEKYELVRIDRKGF
SWQEQTPYLSVVDILRARRSSGLLKTNVK

Nucleotide

• Length: 330 bp

>T110103 NZ_CP031792:c1171312-1170983 [Klebsiella pneumoniae]
ATGAAAACTCTACCTGCTACAATTTCGCGGGCGGCGAAGCCCTGTCTGTCGCCCGTTGCAGTCTGGCAAATGTTACTTAC
TCGTCTGCTTGAGCAGCACTATGGCCTAATGCTAAGCGACACACCTTTTAGCGATGAAACCGTTATAAAGGAGCATATCG
ATGCCGGTATCACTCTGGCTAATGCTGTTAATTTTCTGGTGGAAAAATACGAACTGGTTCGTATCGACCGAAAGGGATTT
TCGTGGCAAGAACAAACCCCGTATCTTTCCGTAGTGGATATTCTGCGAGCAAGGCGCTCTAGCGGCTTGCTAAAAACTAA
CGTGAAATAA

Antitoxin

Protein

• Length: 106 a.a.
• Molecular weight: 11837.43 Da
• Isoelectric Point: 6.8407

>AT110103 WP_047358935.1 NZ_CP031792:c1171650-1171333 [Klebsiella pneumoniae]
MSNITWGLQRDTTPRLGARLVQEGNQLHYLADRASITGKFSDAECFKLDVAFPHFISQMESMLTTGEMNPRHARCVTLYH
NGFTCEADTLGSCGYVYIAIYPTQR

Nucleotide

• Length: 318 bp

>AT110103 NZ_CP031792:c1171650-1171333 [Klebsiella pneumoniae]
ATGAGCAACATTACATGGGGCCTGCAGCGGGATACCACGCCGCGTCTGGGAGCCCGTCTGGTACAGGAGGGGAACCAACT
GCATTATCTGGCTGACCGGGCCAGTATCACCGGTAAGTTTAGTGATGCCGAATGTTTTAAGCTGGATGTGGCATTTCCGC
ATTTTATCAGTCAGATGGAATCGATGCTGACCACTGGTGAAATGAATCCCCGCCATGCCCGCTGTGTCACCCTGTACCAC
AACGGTTTCACCTGCGAAGCCGATACCCTTGGTAGTTGCGGCTACGTATACATCGCCATTTATCCCACTCAACGCTAA