Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 4579261..4579809 Replicon chromosome
Accession NZ_CP031780
Organism Yersinia pseudotuberculosis strain FDAARGOS_342

Toxin (Protein)


Gene name relE Uniprot ID A0A3G5KNV7
Locus tag CEQ20_RS21355 Protein ID WP_072080376.1
Coordinates 4579513..4579809 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A3G5KKQ2
Locus tag CEQ20_RS21350 Protein ID WP_050090618.1
Coordinates 4579261..4579509 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CEQ20_RS21305 4574490..4575323 + 834 WP_057532449.1 DUF945 domain-containing protein -
CEQ20_RS21310 4575335..4575558 + 224 Protein_3958 DUF905 domain-containing protein -
CEQ20_RS21315 4575633..4576103 + 471 WP_057532450.1 antirestriction protein -
CEQ20_RS21320 4576113..4576586 + 474 WP_050090624.1 DNA repair protein RadC -
CEQ20_RS21325 4576596..4576817 + 222 WP_050090623.1 DUF987 domain-containing protein -
CEQ20_RS21330 4576849..4577217 + 369 WP_050090622.1 type IV toxin-antitoxin system YeeU family antitoxin -
CEQ20_RS21335 4577272..4577655 + 384 WP_057532451.1 TA system toxin CbtA family protein -
CEQ20_RS21340 4577652..4578143 + 492 WP_050090620.1 hypothetical protein -
CEQ20_RS23130 4578157..4578318 - 162 WP_155407244.1 hypothetical protein -
CEQ20_RS21345 4578317..4579165 + 849 WP_057532452.1 DUF4942 domain-containing protein -
CEQ20_RS21350 4579261..4579509 + 249 WP_050090618.1 ribbon-helix-helix domain-containing protein Antitoxin
CEQ20_RS21355 4579513..4579809 + 297 WP_072080376.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CEQ20_RS21360 4580147..4581382 + 1236 WP_072091827.1 integrase arm-type DNA-binding domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4563816..4579809 15993


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(9-43)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11801.13 Da        Isoelectric Point: 6.0793

>T110057 WP_072080376.1 NZ_CP031780:4579513-4579809 [Yersinia pseudotuberculosis]
MEIQWTQKAQDDLERIYRFACQYSRQHADNVLERLIIGTSGLADHPRIGVSQTRYEPREVRKILFDDYDVHYEIQRDTIY
IVDLWHTREDRLSSSSSR

Download         Length: 297 bp

>T110057 NZ_CP031780:4579513-4579809 [Yersinia pseudotuberculosis]
ATGGAAATACAGTGGACCCAAAAGGCCCAAGATGACTTGGAGCGTATTTATAGGTTTGCCTGTCAGTACAGTCGGCAACA
TGCTGACAACGTATTAGAACGTTTGATCATAGGAACCTCAGGGCTCGCCGACCATCCAAGAATCGGTGTATCTCAGACAA
GATATGAGCCGCGAGAAGTGAGAAAAATCTTGTTTGATGATTATGACGTTCACTATGAAATTCAGCGCGACACTATTTAT
ATTGTTGACCTTTGGCATACCCGAGAGGATCGCTTAAGTTCGTCATCTTCCAGGTAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9107.51 Da        Isoelectric Point: 8.7560

>AT110057 WP_050090618.1 NZ_CP031780:4579261-4579509 [Yersinia pseudotuberculosis]
MRQLAKQTISAQIPAELAAAVENLAIELDRSKSWVIKEALTAMIEERERRHQQILKGLADVDGGRVVSHADVVDFANKLK
KS

Download         Length: 249 bp

>AT110057 NZ_CP031780:4579261-4579509 [Yersinia pseudotuberculosis]
ATGAGACAACTAGCGAAACAGACGATCAGTGCTCAGATCCCTGCAGAGCTTGCTGCGGCGGTTGAAAACCTGGCTATTGA
ACTGGACAGATCCAAAAGCTGGGTGATTAAGGAAGCGTTAACCGCCATGATTGAAGAGAGAGAGCGGCGTCATCAGCAGA
TTTTGAAAGGGCTTGCTGATGTCGATGGGGGAAGGGTGGTTAGCCATGCGGATGTGGTTGACTTCGCTAACAAACTGAAA
AAATCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G5KNV7

Antitoxin

Source ID Structure
AlphaFold DB A0A3G5KKQ2

References