Detailed information of TA system TA110054

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 3499467..3500239
• Replicon: chromosome
• Accession: NZ_CP031780
• Organism: Yersinia pseudotuberculosis strain FDAARGOS_342

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: A0A3G5KBR0
• Locus tag: CEQ20_RS16190
• Protein ID: WP_050321376.1
• Coordinates: 3499467..3499790 (+)
• Length: 108 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: CEQ20_RS16195
• Protein ID: WP_057532584.1
• Coordinates: 3499871..3500239 (+)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CEQ20_RS16165	3495442..3496263	+	822	WP_050321380.1	DUF945 domain-containing protein	-
CEQ20_RS16170	3496989..3497540	+	552	WP_050321379.1	DUF4339 domain-containing protein	-
CEQ20_RS16175	3498148..3498579	+	432	WP_050321378.1	antirestriction protein	-
CEQ20_RS16180	3498612..3499085	+	474	WP_050093363.1	DNA repair protein RadC	-
CEQ20_RS16185	3499079..3499411	+	333	WP_050321377.1	hypothetical protein	-
CEQ20_RS16190	3499467..3499790	+	324	WP_050321376.1	TA system toxin CbtA family protein	Toxin
CEQ20_RS16195	3499871..3500239	+	369	WP_057532584.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
CEQ20_RS16200	3500319..3501182	+	864	WP_050321374.1	DUF4942 domain-containing protein	-
CEQ20_RS16205	3501384..3501707	+	324	WP_004722490.1	type II toxin-antitoxin system RelE/ParE family toxin	-
CEQ20_RS16210	3501694..3501981	+	288	WP_012104592.1	helix-turn-helix transcriptional regulator	-
CEQ20_RS16215	3502621..3505176	-	2556	WP_050321180.1	M60 family metallopeptidase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3485872..3506751	20879

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (12-98)

Antitoxin

• Antitoxin CbeA (18-116)

Sequences

Toxin

Protein

• Length: 108 a.a.
• Molecular weight: 11989.77 Da
• Isoelectric Point: 6.8791

>T110054 WP_050321376.1 NZ_CP031780:3499467-3499790 [Yersinia pseudotuberculosis]
MKPRPTPPGALTVPAIYQQLLAFLLEHHYGLSLNDTPYHDEQAIAQQIEHGVTVRETVNELVEKFDLVRIDRSGFSMMAQ
DPTLNGGDMLRARSALGLRNPVIRRLA

Nucleotide

• Length: 324 bp

>T110054 NZ_CP031780:3499467-3499790 [Yersinia pseudotuberculosis]
ATGAAACCACGTCCCACCCCACCGGGCGCATTGACCGTGCCTGCGATTTATCAACAACTGCTCGCTTTTCTGCTGGAGCA
CCACTACGGCCTGAGCCTCAACGATACGCCCTATCACGATGAACAGGCGATTGCACAGCAGATTGAGCATGGCGTCACGG
TACGAGAAACCGTCAATGAACTGGTGGAGAAATTTGACCTGGTACGCATTGACCGATCTGGATTCAGCATGATGGCACAG
GACCCGACTTTGAACGGTGGGGATATGTTACGCGCACGCAGTGCATTGGGACTACGCAACCCTGTCATTAGACGCCTTGC
TTGA

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 13422.11 Da
• Isoelectric Point: 6.6292

>AT110054 WP_057532584.1 NZ_CP031780:3499871-3500239 [Yersinia pseudotuberculosis]
MKETQSNATSNDSTPSPVWRLQSAITPRLGARLVQQGNHLHFLADRAGFVGTFEPDALKTLDTAFPVLIEQLEACLRSGE
LDQRRKHCVTVQHASFTCDADTLGSFGHIYIAVYQTTPPNPV

Nucleotide

• Length: 369 bp

>AT110054 NZ_CP031780:3499871-3500239 [Yersinia pseudotuberculosis]
ATGAAGGAAACCCAATCTAATGCCACCAGCAACGACAGCACTCCGTCGCCTGTCTGGCGCCTGCAATCTGCTATCACGCC
CCGCCTGGGAGCCCGGTTGGTCCAGCAGGGTAATCACCTGCATTTTCTAGCAGACCGTGCCGGTTTTGTCGGCACATTTG
AACCTGATGCGCTTAAAACACTGGATACTGCTTTCCCGGTGCTAATTGAACAGTTGGAAGCCTGCCTGCGGTCTGGTGAA
CTCGATCAACGCCGTAAGCATTGCGTCACCGTGCAGCACGCCAGTTTTACCTGCGATGCCGATACGTTAGGTAGCTTTGG
CCACATCTATATCGCTGTTTATCAGACAACACCGCCCAACCCGGTATAA

Structures

Toxin

• AlphaFold DB: A0A3G5KBR0