Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 2717766..2718438 Replicon chromosome
Accession NZ_CP031780
Organism Yersinia pseudotuberculosis strain FDAARGOS_342

Toxin (Protein)


Gene name cptA Uniprot ID Q666S4
Locus tag CEQ20_RS12785 Protein ID WP_002215144.1
Coordinates 2717766..2718191 (-) Length 142 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID Q666S3
Locus tag CEQ20_RS12790 Protein ID WP_002209939.1
Coordinates 2718172..2718438 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CEQ20_RS12765 2713465..2713983 + 519 WP_002209934.1 flavodoxin FldB -
CEQ20_RS12770 2714068..2715525 - 1458 WP_012303664.1 cell envelope integrity protein CreD -
CEQ20_RS12775 2715610..2717043 - 1434 WP_012104678.1 two-component system sensor histidine kinase CreC -
CEQ20_RS12780 2717068..2717766 - 699 WP_002209937.1 two-component system response regulator CreB -
CEQ20_RS12785 2717766..2718191 - 426 WP_002215144.1 protein YgfX Toxin
CEQ20_RS12790 2718172..2718438 - 267 WP_002209939.1 FAD assembly factor SdhE Antitoxin
CEQ20_RS12795 2718754..2719746 + 993 WP_002209940.1 tRNA-modifying protein YgfZ -
CEQ20_RS12800 2719819..2720316 - 498 WP_002209941.1 DUF2165 family protein -
CEQ20_RS12805 2720642..2721343 - 702 WP_002209942.1 hemolysin III family protein -
CEQ20_RS12810 2721544..2722647 - 1104 WP_050320984.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(2-133)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 16510.43 Da        Isoelectric Point: 10.3799

>T110053 WP_002215144.1 NZ_CP031780:c2718191-2717766 [Yersinia pseudotuberculosis]
VAQWRCNLRVSWHTQLFSLLAHGILVILTLVAPWPLGYTALWLVLLTLVVFECIRSQKRIKSCQGEIRLKPGNLVRWKRH
EWTVVKPPWITRYGVLLHLQQTGGHATRKRLWLSADSMSEDEWRQLCLLLRHSFESDDGTM

Download         Length: 426 bp

>T110053 NZ_CP031780:c2718191-2717766 [Yersinia pseudotuberculosis]
GTGGCCCAGTGGCGATGTAACCTGCGGGTATCCTGGCATACTCAACTCTTTTCTTTATTGGCACACGGCATATTGGTCAT
TTTAACCTTGGTCGCGCCCTGGCCCTTGGGTTATACCGCCCTATGGCTGGTATTGCTGACGTTAGTGGTGTTTGAGTGTA
TCCGCAGCCAGAAAAGGATTAAATCCTGTCAGGGGGAAATCAGGCTAAAACCTGGCAACCTGGTGCGATGGAAAAGGCAT
GAATGGACCGTGGTCAAGCCGCCGTGGATCACCCGCTATGGGGTATTATTACATTTACAACAAACAGGCGGCCACGCGAC
CCGAAAGCGTCTATGGCTGTCCGCTGACAGCATGTCTGAAGATGAGTGGCGGCAGCTATGCCTGTTGCTGCGGCATTCAT
TTGAATCTGACGATGGAACGATGTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10511.98 Da        Isoelectric Point: 4.6533

>AT110053 WP_002209939.1 NZ_CP031780:c2718438-2718172 [Yersinia pseudotuberculosis]
MEIDNKARIHWACRRGMRELDISIMPFFEYEYDSLSDNEKQAFIRLLECDDPDLFNWLMNHGEPQDSELYQMVKLIQSRN
KARGPVAM

Download         Length: 267 bp

>AT110053 NZ_CP031780:c2718438-2718172 [Yersinia pseudotuberculosis]
ATGGAAATTGATAATAAAGCCCGTATTCACTGGGCATGCCGCCGTGGTATGCGTGAACTTGATATCTCCATCATGCCGTT
TTTTGAATATGAATATGATAGCTTGAGCGATAACGAGAAACAGGCATTTATCCGCTTGCTTGAGTGTGATGACCCAGATT
TATTCAACTGGCTGATGAACCACGGGGAGCCGCAGGATAGCGAGCTATATCAGATGGTCAAACTGATTCAATCACGAAAT
AAAGCCCGTGGCCCAGTGGCGATGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q666S4

Antitoxin

Source ID Structure
AlphaFold DB A0A0E8XP12

References