Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB-HicA
Location 1824471..1825117 Replicon chromosome
Accession NZ_CP031780
Organism Yersinia pseudotuberculosis strain FDAARGOS_342

Toxin (Protein)


Gene name hicA Uniprot ID A0A2A7VEB5
Locus tag CEQ20_RS08475 Protein ID WP_050105361.1
Coordinates 1824471..1824653 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A2A7VE79
Locus tag CEQ20_RS08480 Protein ID WP_042592976.1
Coordinates 1824698..1825117 (+) Length 140 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CEQ20_RS08450 1821083..1822281 - 1199 Protein_1574 hypothetical protein -
CEQ20_RS08455 1822265..1822624 - 360 WP_057532700.1 hypothetical protein -
CEQ20_RS08460 1822621..1823297 - 677 Protein_1576 hypothetical protein -
CEQ20_RS08465 1823279..1823740 - 462 Protein_1577 hypothetical protein -
CEQ20_RS08470 1823745..1824368 - 624 Protein_1578 TerL protein -
CEQ20_RS08475 1824471..1824653 + 183 WP_050105361.1 type II toxin-antitoxin system HicA family toxin Toxin
CEQ20_RS08480 1824698..1825117 + 420 WP_042592976.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
CEQ20_RS08485 1825398..1826003 - 606 WP_072193999.1 terminase small subunit -
CEQ20_RS08490 1826034..1826402 - 369 WP_057532480.1 hypothetical protein -
CEQ20_RS08495 1826557..1826979 - 423 WP_057532501.1 lysis protein -
CEQ20_RS08505 1827215..1827613 - 399 WP_072186745.1 M15 family metallopeptidase -
CEQ20_RS08510 1827600..1827932 - 333 WP_025383386.1 phage holin, lambda family -
CEQ20_RS08515 1828014..1828745 - 732 WP_057532482.1 hypothetical protein -
CEQ20_RS08520 1829131..1829895 - 765 WP_050128282.1 antitermination protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1815162..1844159 28997


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-131)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6811.02 Da        Isoelectric Point: 11.0775

>T110051 WP_050105361.1 NZ_CP031780:1824471-1824653 [Yersinia pseudotuberculosis]
VKSSELIKRLEANGWKLMRVKGSHHQFKHPDFAAVITVPHPKKDIKPGTLRQILKDANLS

Download         Length: 183 bp

>T110051 NZ_CP031780:1824471-1824653 [Yersinia pseudotuberculosis]
GTGAAAAGTTCGGAGCTGATAAAACGACTCGAAGCAAATGGTTGGAAGTTGATGAGAGTTAAAGGCAGTCATCATCAATT
CAAACATCCTGATTTCGCGGCAGTCATAACAGTACCGCATCCAAAGAAGGACATTAAACCGGGAACCCTCCGGCAAATTC
TGAAAGATGCAAACCTTAGTTAA

Antitoxin


Download         Length: 140 a.a.        Molecular weight: 15448.21 Da        Isoelectric Point: 4.7791

>AT110051 WP_042592976.1 NZ_CP031780:1824698-1825117 [Yersinia pseudotuberculosis]
MAIYPAYVHVDSDGSASGYFPDVKGCIFAIDAGEDLFAEASSALEAHFEALVSEGIEIPEAHDMPFHYHTNPSNYSDGGQ
WYNVSIDMSKYDGKAERINVTLPHRLIHQIDTIVKVRPEYASRSNFLAEAARKELQKLA

Download         Length: 420 bp

>AT110051 NZ_CP031780:1824698-1825117 [Yersinia pseudotuberculosis]
ATGGCTATCTATCCCGCATACGTTCATGTCGATAGTGATGGCTCGGCAAGCGGTTATTTCCCTGACGTCAAAGGCTGTAT
TTTTGCCATTGATGCCGGAGAGGATTTATTTGCAGAGGCATCAAGCGCCCTGGAGGCGCACTTTGAGGCGTTGGTGTCTG
AGGGTATTGAGATACCCGAGGCGCATGATATGCCTTTCCACTACCACACCAATCCGAGCAATTACAGTGACGGCGGCCAG
TGGTATAACGTGAGTATTGATATGTCAAAATATGACGGAAAAGCCGAGCGGATTAACGTCACTCTTCCTCACCGGCTGAT
CCATCAAATCGATACCATTGTTAAGGTGCGTCCAGAGTACGCCAGCCGGAGTAATTTTCTAGCCGAAGCAGCACGTAAAG
AATTACAGAAATTAGCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A7VEB5

Antitoxin

Source ID Structure
AlphaFold DB A0A2A7VE79

References