Detailed information of TA system TA110042

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /COG5642-COG5654
• Location: 1064233..1065208
• Replicon: chromosome
• Accession: NZ_CP031780
• Organism: Yersinia pseudotuberculosis strain FDAARGOS_342

Toxin (Protein)

• Gene name: -
• Uniprot ID: Q66A68
• Locus tag: CEQ20_RS04980
• Protein ID: WP_011192520.1
• Coordinates: 1064233..1064691 (-)
• Length: 153 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: Q66A69
• Locus tag: CEQ20_RS04985
• Protein ID: WP_002210982.1
• Coordinates: 1064762..1065208 (-)
• Length: 149 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CEQ20_RS04950	1060047..1060712	+	666	WP_011192521.1	phage shock protein PspA	-
CEQ20_RS04955	1060874..1061101	+	228	WP_002210976.1	envelope stress response membrane protein PspB	-
CEQ20_RS04960	1061101..1061460	+	360	WP_002210977.1	envelope stress response membrane protein PspC	-
CEQ20_RS04965	1061545..1061787	+	243	WP_080987533.1	phage shock protein PspD	-
CEQ20_RS04970	1061768..1063165	+	1398	WP_057532366.1	YcjX family protein	-
CEQ20_RS04975	1063162..1064223	+	1062	WP_050320586.1	YcjF family protein	-
CEQ20_RS04980	1064233..1064691	-	459	WP_011192520.1	RES family NAD+ phosphorylase	Toxin
CEQ20_RS04985	1064762..1065208	-	447	WP_002210982.1	DUF2384 domain-containing protein	Antitoxin
CEQ20_RS04990	1065546..1067123	+	1578	WP_050320587.1	transcriptional regulator TyrR	-
CEQ20_RS04995	1067270..1067773	-	504	WP_057532365.1	thiol peroxidase	-
CEQ20_RS05000	1067936..1068910	+	975	WP_002210985.1	L-Ala-D/L-Glu epimerase	-
CEQ20_RS05005	1068969..1069676	-	708	WP_002220315.1	murein tripeptide amidase MpaA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (2-147)

Antitoxin

• Antitoxin Xre (15-147)

Sequences

Toxin

Protein

• Length: 153 a.a.
• Molecular weight: 17008.41 Da
• Isoelectric Point: 4.8732

>T110042 WP_011192520.1 NZ_CP031780:c1064691-1064233 [Yersinia pseudotuberculosis]
MTLYRIVMRRYLASAWTGYGAEIYGGRWNHKGHAAIYLASSISLAMLETLAHIQDSSTLSEFELFQIEISDSSIMLLQPQ
DWPTDWRSDPAPVATMDVGTEWLESESSLGLLVPSTLVPSENNLLVNPHHKDFPACLASVKPLSFVFDPRLK

Nucleotide

• Length: 459 bp

>T110042 NZ_CP031780:c1064691-1064233 [Yersinia pseudotuberculosis]
ATGACGCTATACCGCATTGTTATGCGCCGCTATCTTGCATCGGCATGGACTGGTTACGGCGCTGAAATCTATGGTGGTCG
TTGGAATCATAAAGGCCATGCTGCCATCTATTTAGCCAGCAGTATTTCATTGGCTATGCTCGAAACACTGGCTCATATTC
AGGACAGTTCAACACTCAGCGAATTTGAATTATTCCAAATTGAAATCAGTGACAGCAGTATTATGTTGCTACAGCCGCAG
GACTGGCCCACGGATTGGCGTAGCGATCCGGCACCGGTGGCAACGATGGATGTCGGCACCGAGTGGCTGGAATCAGAATC
CTCGCTAGGCTTACTGGTCCCGTCCACGTTGGTGCCGTCAGAAAACAACCTACTGGTCAATCCTCATCACAAAGATTTTC
CAGCGTGTTTGGCCAGCGTCAAACCGCTCTCTTTTGTCTTTGATCCACGGTTAAAATAG

Antitoxin

Protein

• Length: 149 a.a.
• Molecular weight: 16401.94 Da
• Isoelectric Point: 9.7155

>AT110042 WP_002210982.1 NZ_CP031780:c1065208-1064762 [Yersinia pseudotuberculosis]
MRAYRPNPATKMGTLWREIGLPASRGTILVDSIKMGFSVDVIDSIHLWASMPKAEILRATGIPSRSLTRRRTHDGRFTPE
ESERIARFVRVMDAAVDLFGGDKGKAITWMSTPIKGLGYRSPDSLLETETGALEVCDLIGRLEHGVFT

Nucleotide

• Length: 447 bp

>AT110042 NZ_CP031780:c1065208-1064762 [Yersinia pseudotuberculosis]
ATGAGAGCGTACCGCCCAAACCCCGCGACTAAAATGGGAACGCTTTGGCGTGAAATTGGCTTACCCGCCAGCCGCGGCAC
GATATTGGTCGATAGTATCAAAATGGGGTTTTCTGTTGATGTTATCGACAGCATTCATTTATGGGCATCCATGCCTAAAG
CTGAAATATTACGTGCTACCGGTATCCCCAGCCGTAGCCTGACTCGCCGCCGCACACATGATGGCCGTTTTACGCCTGAA
GAAAGCGAGAGAATCGCACGTTTTGTCCGCGTAATGGATGCCGCTGTCGATTTGTTCGGCGGCGATAAAGGTAAAGCCAT
TACCTGGATGTCCACGCCCATCAAAGGATTAGGGTATCGCAGCCCAGACTCCTTACTGGAAACCGAAACTGGCGCACTGG
AAGTGTGTGATTTGATTGGTCGTTTGGAACACGGCGTCTTTACTTAA

Structures

Toxin

• AlphaFold DB: Q66A68

Antitoxin

• AlphaFold DB: A0A0E8XFL1