Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB-HicA
Location 856883..857529 Replicon chromosome
Accession NZ_CP031780
Organism Yersinia pseudotuberculosis strain FDAARGOS_342

Toxin (Protein)


Gene name hicA Uniprot ID A0A2A7VEB5
Locus tag CEQ20_RS04005 Protein ID WP_050105361.1
Coordinates 857347..857529 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A2A7VE79
Locus tag CEQ20_RS04000 Protein ID WP_042592976.1
Coordinates 856883..857302 (-) Length 140 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CEQ20_RS03965 853309..854040 + 732 WP_050128283.1 hypothetical protein -
CEQ20_RS03970 854121..854453 + 333 WP_042592972.1 phage holin, lambda family -
CEQ20_RS03975 854440..854838 + 399 WP_192963081.1 M15 family metallopeptidase -
CEQ20_RS03980 854835..855224 + 390 WP_118948986.1 exotoxin -
CEQ20_RS03990 855577..855759 + 183 WP_098087201.1 hypothetical protein -
CEQ20_RS03995 855985..856602 + 618 WP_192963082.1 terminase small subunit -
CEQ20_RS04000 856883..857302 - 420 WP_042592976.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
CEQ20_RS04005 857347..857529 - 183 WP_050105361.1 type II toxin-antitoxin system HicA family toxin Toxin
CEQ20_RS04010 857632..858507 + 876 Protein_737 TerL protein -
CEQ20_RS04015 858503..858931 + 429 Protein_738 hypothetical protein -
CEQ20_RS04020 858933..859235 + 303 WP_012105513.1 hypothetical protein -
CEQ20_RS04025 859239..860078 + 840 WP_098087202.1 hypothetical protein -
CEQ20_RS04030 860060..860737 + 678 WP_042592987.1 hypothetical protein -
CEQ20_RS04035 860734..861093 + 360 WP_057532700.1 hypothetical protein -
CEQ20_RS04040 861077..862275 + 1199 Protein_743 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 843114..867034 23920


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-131)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6811.02 Da        Isoelectric Point: 11.0775

>T110041 WP_050105361.1 NZ_CP031780:c857529-857347 [Yersinia pseudotuberculosis]
VKSSELIKRLEANGWKLMRVKGSHHQFKHPDFAAVITVPHPKKDIKPGTLRQILKDANLS

Download         Length: 183 bp

>T110041 NZ_CP031780:c857529-857347 [Yersinia pseudotuberculosis]
GTGAAAAGTTCGGAGCTGATAAAACGACTCGAAGCAAATGGTTGGAAGTTGATGAGAGTTAAAGGCAGTCATCATCAATT
CAAACATCCTGATTTCGCGGCAGTCATAACAGTACCGCATCCAAAGAAGGACATTAAACCGGGAACCCTCCGGCAAATTC
TGAAAGATGCAAACCTTAGTTAA

Antitoxin


Download         Length: 140 a.a.        Molecular weight: 15448.21 Da        Isoelectric Point: 4.7791

>AT110041 WP_042592976.1 NZ_CP031780:c857302-856883 [Yersinia pseudotuberculosis]
MAIYPAYVHVDSDGSASGYFPDVKGCIFAIDAGEDLFAEASSALEAHFEALVSEGIEIPEAHDMPFHYHTNPSNYSDGGQ
WYNVSIDMSKYDGKAERINVTLPHRLIHQIDTIVKVRPEYASRSNFLAEAARKELQKLA

Download         Length: 420 bp

>AT110041 NZ_CP031780:c857302-856883 [Yersinia pseudotuberculosis]
ATGGCTATCTATCCCGCATACGTTCATGTCGATAGTGATGGCTCGGCAAGCGGTTATTTCCCTGACGTCAAAGGCTGTAT
TTTTGCCATTGATGCCGGAGAGGATTTATTTGCAGAGGCATCAAGCGCCCTGGAGGCGCACTTTGAGGCGTTGGTGTCTG
AGGGTATTGAGATACCCGAGGCGCATGATATGCCTTTCCACTACCACACCAATCCGAGCAATTACAGTGACGGCGGCCAG
TGGTATAACGTGAGTATTGATATGTCAAAATATGACGGAAAAGCCGAGCGGATTAACGTCACTCTTCCTCACCGGCTGAT
CCATCAAATCGATACCATTGTTAAGGTGCGTCCAGAGTACGCCAGCCGGAGTAATTTTCTAGCCGAAGCAGCACGTAAAG
AATTACAGAAATTAGCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A7VEB5

Antitoxin

Source ID Structure
AlphaFold DB A0A2A7VE79

References