Detailed information of TA system TA110040

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 309448..310224
• Replicon: chromosome
• Accession: NZ_CP031780
• Organism: Yersinia pseudotuberculosis strain FDAARGOS_342

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: A0A0H3B6R1
• Locus tag: CEQ20_RS01440
• Protein ID: WP_012304462.1
• Coordinates: 309841..310224 (+)
• Length: 128 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: A0A0H3B780
• Locus tag: CEQ20_RS01435
• Protein ID: WP_012304463.1
• Coordinates: 309448..309777 (+)
• Length: 110 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CEQ20_RS01400	305773..306660	+	888	WP_012304468.1	50S ribosome-binding GTPase	-
CEQ20_RS01415	307161..307625	+	465	WP_012304467.1	hypothetical protein	-
CEQ20_RS01420	307646..307984	+	339	WP_012304466.1	hypothetical protein	-
CEQ20_RS01425	308073..308894	+	822	WP_012304465.1	DUF945 domain-containing protein	-
CEQ20_RS01430	308965..309435	+	471	WP_012304464.1	DNA repair protein RadC	-
CEQ20_RS01435	309448..309777	+	330	WP_012304463.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
CEQ20_RS01440	309841..310224	+	384	WP_012304462.1	TA system toxin CbtA family protein	Toxin
CEQ20_RS01445	310221..310716	+	496	Protein_260	hypothetical protein	-
CEQ20_RS01450	310891..311739	+	849	WP_012304460.1	DUF4942 domain-containing protein	-
CEQ20_RS01455	311986..312168	-	183	WP_041175786.1	AlpA family phage regulatory protein	-
CEQ20_RS01460	312427..312627	-	201	WP_011191898.1	hypothetical protein	-
CEQ20_RS01465	312741..313388	-	648	WP_012304420.1	hypothetical protein	-
CEQ20_RS01470	313373..313711	-	339	WP_002215266.1	hypothetical protein	-
CEQ20_RS01475	313794..314072	-	279	WP_079866998.1	tyrosine-type recombinase/integrase	-
CEQ20_RS01480	314284..314490	+	207	WP_002354559.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-112)

Antitoxin

• Antitoxin CbeA (7-106)

Sequences

Toxin

Protein

• Length: 128 a.a.
• Molecular weight: 14442.40 Da
• Isoelectric Point: 8.9291

>T110040 WP_012304462.1 NZ_CP031780:309841-310224 [Yersinia pseudotuberculosis]
MQTLPVNPKRAAQTCPSPVEIWQKLLTHLLDQHYGLTLSDTSFSNETTIREHIDAGISLSYAVNFLVEKYELVRTDRTSF
TIVEQSPFITPIDILRARQATGLLKRSGYKAVSDITRGRARREEQSH

Nucleotide

• Length: 384 bp

>T110040 NZ_CP031780:309841-310224 [Yersinia pseudotuberculosis]
ATGCAAACCTTACCCGTAAACCCGAAACGGGCGGCACAAACCTGCCCGTCACCTGTTGAAATATGGCAAAAACTGCTAAC
GCATCTGCTCGATCAACACTATGGACTCACACTTAGTGATACCTCGTTCAGCAATGAAACCACCATCCGTGAACATATTG
ACGCCGGAATATCCCTCAGCTATGCGGTGAACTTCCTGGTGGAAAAATATGAACTGGTACGCACTGACCGGACCAGTTTC
ACCATTGTGGAGCAATCACCGTTTATCACCCCAATCGATATTCTCCGCGCCAGGCAAGCCACCGGTCTCCTGAAGCGCAG
TGGTTATAAAGCCGTCAGTGACATTACCCGTGGCAGAGCTCGGCGAGAGGAGCAAAGCCATTGA

Antitoxin

Protein

• Length: 110 a.a.
• Molecular weight: 12234.84 Da
• Isoelectric Point: 6.4825

>AT110040 WP_012304463.1 NZ_CP031780:309448-309777 [Yersinia pseudotuberculosis]
MSLTLSHEWGLKSDITPRFGARLVQEGNRLHFRADHAGFNGAFSEDEALRLDQAFPLMLKQLELKLLSGELNPRRQHCVT
LNHNGLTCEADTLGSHGYVYITIYPASPE

Nucleotide

• Length: 330 bp

>AT110040 NZ_CP031780:309448-309777 [Yersinia pseudotuberculosis]
ATGTCATTAACACTATCCCATGAATGGGGGCTAAAAAGCGATATCACCCCACGCTTTGGCGCAAGATTGGTGCAGGAAGG
CAATCGCCTGCACTTTCGGGCTGACCATGCGGGTTTTAACGGTGCATTCAGTGAGGATGAGGCGCTGCGGCTTGACCAAG
CGTTTCCACTGATGCTCAAACAGCTTGAACTTAAGCTGCTATCCGGTGAGCTCAATCCTCGTCGTCAGCATTGCGTTACG
TTGAACCACAATGGCCTGACCTGCGAAGCTGACACCCTCGGCTCTCACGGGTATGTCTATATCACTATTTACCCGGCAAG
CCCGGAATAA

Structures

Toxin

• AlphaFold DB: A0A0H3B6R1

Antitoxin

• AlphaFold DB: A0A0H3B780