Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 861011..861488 Replicon chromosome
Accession NZ_CP031779
Organism Staphylococcus aureus strain CFBR-105

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag D1F65_RS04250 Protein ID WP_000052076.1
Coordinates 861011..861199 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag D1F65_RS04255 Protein ID WP_001059690.1
Coordinates 861228..861488 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D1F65_RS04220 857005..857526 + 522 WP_000824482.1 hypothetical protein -
D1F65_RS04225 857867..858553 + 687 WP_000141557.1 thermonuclease family protein -
D1F65_RS04230 858910..859110 + 201 WP_001059082.1 cold-shock protein -
D1F65_RS04235 859602..859820 - 219 WP_000005886.1 hypothetical protein -
D1F65_RS04240 859897..860166 - 270 WP_001004398.1 hypothetical protein -
D1F65_RS04245 860254..860823 - 570 WP_001106658.1 hypothetical protein -
D1F65_RS04250 861011..861199 - 189 WP_000052076.1 hypothetical protein Toxin
D1F65_RS04255 861228..861488 - 261 WP_001059690.1 hypothetical protein Antitoxin
D1F65_RS04260 861829..862032 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
D1F65_RS04265 862029..862265 - 237 WP_000349581.1 hypothetical protein -
D1F65_RS04270 862490..863071 + 582 WP_001140693.1 phosphoglycerate mutase family protein -
D1F65_RS04275 863144..863761 - 618 WP_000255551.1 LysE/ArgO family amino acid transporter -
D1F65_RS04280 863916..864410 - 495 WP_000569883.1 GNAT family N-acetyltransferase -
D1F65_RS04285 864809..865231 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
D1F65_RS04290 865379..866095 + 717 WP_000150011.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(7-103)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T110028 WP_000052076.1 NZ_CP031779:c861199-861011 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T110028 NZ_CP031779:c861199-861011 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT110028 WP_001059690.1 NZ_CP031779:c861488-861228 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT110028 NZ_CP031779:c861488-861228 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References