Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 553927..555533 Replicon chromosome
Accession NZ_CP031775
Organism Shewanella decolorationis strain Ni1-3

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag D0436_RS02445 Protein ID WP_208660396.1
Coordinates 554205..555533 (+) Length 443 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag D0436_RS02440 Protein ID WP_208660398.1
Coordinates 553927..554205 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D0436_RS02425 (D0436_20380) 549780..550331 - 552 WP_208660404.1 NAD(P)H-dependent oxidoreductase -
D0436_RS02430 (D0436_20375) 550597..551718 + 1122 WP_208660402.1 hypothetical protein -
D0436_RS02435 (D0436_20370) 551728..552900 - 1173 WP_208660400.1 MerR family transcriptional regulator -
D0436_RS02440 (D0436_20365) 553927..554205 + 279 WP_208660398.1 helix-turn-helix domain-containing protein Antitoxin
D0436_RS02445 (D0436_20360) 554205..555533 + 1329 WP_208660396.1 type II toxin-antitoxin system HipA family toxin Toxin
D0436_RS02450 (D0436_20355) 555771..556595 + 825 WP_208660394.1 hypothetical protein -
D0436_RS02455 (D0436_20350) 556681..556902 + 222 WP_208660392.1 AlpA family phage regulatory protein -
D0436_RS02460 (D0436_20345) 556902..557108 + 207 WP_157705913.1 AlpA family phage regulatory protein -
D0436_RS02465 (D0436_20340) 557331..558149 + 819 WP_208660390.1 inovirus-type Gp2 protein -
D0436_RS02470 (D0436_20335) 558368..559018 + 651 WP_208660388.1 HGGxSTG domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 553927..567278 13351


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 443 a.a.        Molecular weight: 49029.00 Da        Isoelectric Point: 7.1957

>T110024 WP_208660396.1 NZ_CP031775:554205-555533 [Shewanella decolorationis]
MAALDVYMNGYLVGEFIKTPTGAHQFKYHEDWLALAGSRPISLSMPLRRQAYIGDEVYNFFDNLLPDNPEVRNRIVARHQ
AASSQPFDLLAKIGQDSVGALQLIPQGELPINVRQIDAKPLSSAELEKVLKGYLSGIPLGMLREQDDFRISIAGAQEKTA
LLNIDGKWCLPLHATPTTHIIKLPIGTIKGHSFDIDMSDSVENEYLCMKIAKAFGLAVAGCNIMKVGDIKALVVERFDRR
LASDGSWLMRLPQEDFCQVLNVPPAKKYESDGGPGIQEIMAQLLGSAMPERDRHDFMKAQVLFWLLGAIDGHAKNFSIFI
DAGGGYRLTPLYDILSIYPALGGKGPNIRDVKLAMALKGSKGKKVLLESIFPRHFILTAKTVGFDTDSMVGIMTEMADIL
DFVIMKVSRELPDDFPVQIRDSIINGLKKRAQRLSIENLTRF

Download         Length: 1329 bp

>T110024 NZ_CP031775:554205-555533 [Shewanella decolorationis]
ATGGCGGCGTTAGATGTCTACATGAATGGTTATCTAGTTGGCGAATTTATCAAAACTCCGACAGGTGCCCACCAATTCAA
GTATCACGAGGATTGGCTTGCATTGGCAGGTAGCCGCCCCATATCACTATCAATGCCACTACGAAGGCAAGCTTATATCG
GCGATGAGGTTTACAACTTCTTCGATAACCTATTGCCCGATAATCCCGAAGTTCGTAACCGCATTGTTGCTCGCCATCAA
GCCGCTTCCTCGCAGCCTTTTGACTTGCTTGCAAAGATTGGACAAGACAGTGTTGGTGCATTGCAATTAATTCCTCAAGG
CGAGTTGCCCATTAATGTTAGGCAGATAGATGCTAAACCGCTGTCTTCTGCTGAGCTAGAAAAGGTATTGAAAGGTTATT
TGTCTGGTATTCCGTTAGGTATGCTCAGGGAGCAAGATGATTTCAGGATCTCTATAGCAGGTGCCCAGGAAAAAACTGCG
CTGCTCAATATAGATGGGAAGTGGTGTTTGCCGCTTCATGCAACACCGACAACACATATTATTAAATTGCCCATTGGTAC
TATAAAGGGTCATTCGTTTGATATAGATATGTCTGATAGCGTGGAAAACGAATATCTTTGTATGAAGATCGCTAAGGCAT
TTGGCCTTGCTGTAGCTGGATGTAACATCATGAAAGTCGGTGATATTAAAGCGCTTGTTGTTGAGCGATTTGATCGACGT
TTAGCATCCGATGGCAGTTGGTTAATGCGTCTTCCACAAGAGGATTTTTGTCAGGTTCTGAATGTACCACCAGCAAAGAA
ATATGAAAGCGATGGTGGGCCAGGAATCCAAGAAATCATGGCTCAACTACTGGGGTCCGCAATGCCAGAACGAGACAGGC
ATGATTTCATGAAGGCTCAAGTCTTGTTTTGGTTACTGGGTGCTATTGATGGTCACGCTAAAAACTTCTCAATTTTTATT
GATGCTGGTGGCGGTTATCGATTAACTCCCCTTTACGATATTTTATCGATCTATCCGGCTCTTGGAGGCAAAGGGCCTAA
CATTCGCGATGTAAAGCTGGCAATGGCGTTGAAGGGCAGTAAAGGTAAAAAGGTACTGCTAGAAAGCATATTTCCAAGAC
ACTTTATTCTGACTGCTAAAACTGTGGGATTTGATACTGACAGTATGGTAGGGATTATGACTGAAATGGCCGATATACTC
GATTTTGTGATCATGAAAGTCAGCAGAGAGCTTCCCGATGATTTTCCTGTACAAATACGCGATTCGATTATCAATGGATT
AAAGAAAAGGGCTCAGCGCCTGAGCATCGAAAATCTTACTCGATTTTAG

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10469.90 Da        Isoelectric Point: 9.6559

>AT110024 WP_208660398.1 NZ_CP031775:553927-554205 [Shewanella decolorationis]
MKVTTAKQLSNYLKDTRLSLKLSQSKVANKVGIRQDTVSSFEQNPDSTKLETLFKLLASLNLELEVKKRGASIDNIRLDN
TSLDGQDWKEEW

Download         Length: 279 bp

>AT110024 NZ_CP031775:553927-554205 [Shewanella decolorationis]
ATGAAAGTGACAACAGCTAAACAGCTAAGTAATTATCTTAAAGATACTCGTCTATCCTTGAAGCTTTCTCAAAGCAAAGT
GGCTAATAAAGTTGGCATTCGCCAAGATACAGTATCAAGCTTCGAGCAAAACCCCGATTCCACAAAGCTGGAGACGCTTT
TTAAGCTCCTGGCGTCGCTCAATCTTGAATTAGAGGTTAAGAAGAGAGGAGCTAGCATTGATAATATTCGCTTGGATAAC
ACCTCATTAGATGGCCAAGACTGGAAAGAGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References