Detailed information of TA system TA110023

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-YefM
• Location: 404862..405412
• Replicon: chromosome
• Accession: NZ_CP031775
• Organism: Shewanella decolorationis strain Ni1-3

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: D0436_RS01780
• Protein ID: WP_208661166.1
• Coordinates: 404862..405161 (-)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: V1DMX4
• Locus tag: D0436_RS01785
• Protein ID: WP_023266112.1
• Coordinates: 405170..405412 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D0436_RS01745 (D0436_01840)	400050..400214	-	165	WP_235056983.1	hypothetical protein	-
D0436_RS01750 (D0436_01845)	400256..400579	-	324	WP_208661162.1	rhodanese-like domain-containing protein	-
D0436_RS01755 (D0436_01850)	400674..401249	-	576	WP_023268225.1	XRE family transcriptional regulator	-
D0436_RS01760 (D0436_01855)	401377..402564	+	1188	WP_208662873.1	benzoate/H(+) symporter BenE family transporter	-
D0436_RS01765 (D0436_01860)	402624..403079	-	456	WP_208661163.1	GNAT family N-acetyltransferase	-
D0436_RS01770 (D0436_01865)	403711..404247	+	537	WP_208661164.1	hypothetical protein	-
D0436_RS01775 (D0436_23520)	404645..404812	+	168	WP_208661165.1	hypothetical protein	-
D0436_RS01780 (D0436_01870)	404862..405161	-	300	WP_208661166.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
D0436_RS01785 (D0436_01875)	405170..405412	-	243	WP_023266112.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
D0436_RS01790 (D0436_01880)	405606..406349	-	744	WP_208661167.1	hypothetical protein	-
D0436_RS01795 (D0436_01885)	406360..406905	-	546	Protein_353	beta-ketoacyl-ACP synthase	-
D0436_RS01800 (D0436_01890)	407402..408196	+	795	Protein_354	SulP family inorganic anion transporter	-
D0436_RS01805 (D0436_23525)	408261..408965	+	705	WP_001067855.1	IS6-like element IS26 family transposase	-
D0436_RS01810 (D0436_23215)	409018..409815	+	798	Protein_356	Tn3 family transposase	-
D0436_RS01815 (D0436_23220)	409917..410378	+	462	WP_198478452.1	DMT family transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-90)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-55)

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11557.33 Da
• Isoelectric Point: 9.8453

>T110023 WP_208661166.1 NZ_CP031775:c405161-404862 [Shewanella decolorationis]
MNNKRYKLSRLAQAHLLKIKDYTLQHFSESQWHKYKENLISGLQMLANHPGLGRSCNDIYPNGFYFPIGKHTAYFTKEDD
FILIVALLGQPQLPQNHLK

Nucleotide

• Length: 300 bp

>T110023 NZ_CP031775:c405161-404862 [Shewanella decolorationis]
ATGAATAATAAACGTTATAAACTGAGTAGGTTAGCTCAGGCTCACCTACTAAAGATTAAAGACTACACCCTTCAACACTT
TTCTGAGTCGCAGTGGCACAAATATAAAGAAAACCTTATATCCGGTTTGCAAATGTTAGCCAATCACCCCGGATTAGGCA
GAAGCTGCAACGATATTTACCCCAACGGTTTCTACTTTCCTATCGGTAAACACACAGCCTACTTCACCAAAGAAGACGAC
TTCATCCTTATCGTTGCCCTGTTAGGTCAACCACAGCTACCCCAAAATCATCTGAAATAG

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8954.13 Da
• Isoelectric Point: 4.7483

>AT110023 WP_023266112.1 NZ_CP031775:c405412-405170 [Shewanella decolorationis]
MQTLTANDAKRNFGELLLNAQREPIKISKNSKDAVVVMSIHDYEQLEAMKADYLKHCFNAAKEDLAQGNVVDGEDFLNAL

Nucleotide

• Length: 243 bp

>AT110023 NZ_CP031775:c405412-405170 [Shewanella decolorationis]
ATGCAAACATTAACCGCCAATGACGCCAAACGAAATTTCGGTGAGTTGCTGCTAAACGCTCAACGTGAACCCATCAAGAT
CAGCAAAAACAGTAAAGATGCGGTTGTGGTCATGTCTATCCACGATTACGAACAGCTTGAGGCGATGAAAGCCGACTATC
TGAAGCACTGTTTCAACGCTGCTAAAGAAGACTTAGCGCAAGGTAATGTTGTTGATGGCGAAGATTTTCTTAACGCCCTG
TAG

Structures

Antitoxin

• AlphaFold DB: V1DMX4