Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3013372..3013991 Replicon chromosome
Accession NZ_CP031756
Organism Klebsiella aerogenes strain FDAARGOS_327

Toxin (Protein)


Gene name Hha Uniprot ID A0A0H3FXE2
Locus tag CEQ05_RS15085 Protein ID WP_015367918.1
Coordinates 3013372..3013590 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A0H3FPM3
Locus tag CEQ05_RS15090 Protein ID WP_015367917.1
Coordinates 3013617..3013991 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CEQ05_RS15055 3009445..3009705 + 261 WP_015367923.1 type B 50S ribosomal protein L31 -
CEQ05_RS15060 3009708..3009848 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
CEQ05_RS15065 3009845..3010555 - 711 WP_015367922.1 GNAT family N-acetyltransferase -
CEQ05_RS15070 3010658..3012112 + 1455 WP_015367921.1 PLP-dependent aminotransferase family protein -
CEQ05_RS15075 3012087..3012551 - 465 WP_015367920.1 YlaC family protein -
CEQ05_RS15080 3012677..3013240 - 564 WP_015367919.1 maltose O-acetyltransferase -
CEQ05_RS15085 3013372..3013590 - 219 WP_015367918.1 hemolysin expression modulator Hha Toxin
CEQ05_RS15090 3013617..3013991 - 375 WP_015367917.1 Hha toxicity modulator TomB Antitoxin
CEQ05_RS15095 3014464..3017610 - 3147 WP_015367916.1 multidrug efflux RND transporter permease subunit -
CEQ05_RS15100 3017633..3018832 - 1200 WP_020079451.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8569.96 Da        Isoelectric Point: 9.4828

>T109999 WP_015367918.1 NZ_CP031756:c3013590-3013372 [Klebsiella aerogenes]
MSGKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T109999 NZ_CP031756:c3013590-3013372 [Klebsiella aerogenes]
ATGTCTGGTAAACCATTAACTAAAACAGACTATTTGATGCGTTTACGCCGCTGTCAGACAATTGATACGCTGGAGCGCGT
AATTGAAAAGAATAAATATGAACTTTCCGACAATGAATTGGCGGTATTTTACTCAGCAGCCGACCATCGTCTTGCTGAAT
TGACCATGAATAAGCTATACGACAAAATCCCAACTTCAGTATGGAAATTTATCCGCTAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14464.21 Da        Isoelectric Point: 4.9045

>AT109999 WP_015367917.1 NZ_CP031756:c3013991-3013617 [Klebsiella aerogenes]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNRGWVNDPTSAVNLQLNELIEHIATYALNYKIKYAEDNKLISQLDEYL
DDTFMLFSSYGINTSDLQKWRKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT109999 NZ_CP031756:c3013991-3013617 [Klebsiella aerogenes]
ATGGACGAGTACTCGCCAAAAAGACATGATATCGCGCAGCTAAGATTTCTCTGCGAAACGTTGTATCATGACTGCCTTGC
AAACCTGGAAGAAAGCAACCGCGGCTGGGTTAACGATCCCACCTCGGCGGTGAATCTTCAATTAAATGAATTGATCGAGC
ACATAGCAACTTACGCGCTTAATTATAAAATTAAGTACGCTGAGGATAATAAGCTGATTTCTCAGCTTGATGAATACCTG
GATGACACTTTTATGCTGTTCAGTAGCTATGGCATAAACACAAGCGATCTCCAAAAATGGCGCAAATCCGGCAATCGGTT
ATTCCGATGCTTTGTGAACGCCAGCCGGGAGAACCCGGCAAGTCTTTCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3FXE2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3FPM3

References