Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ypjF-yeeU/CbtA-CbeA
Location 558673..559453 Replicon chromosome
Accession NZ_CP031756
Organism Klebsiella aerogenes strain FDAARGOS_327

Toxin (Protein)


Gene name ypjF Uniprot ID -
Locus tag CEQ05_RS02830 Protein ID WP_015370123.1
Coordinates 559124..559453 (+) Length 110 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag CEQ05_RS02825 Protein ID WP_127175768.1
Coordinates 558673..559071 (+) Length 133 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CEQ05_RS02775 554132..554539 + 408 WP_032710459.1 hypothetical protein -
CEQ05_RS02780 554612..554839 + 228 WP_015370132.1 hypothetical protein -
CEQ05_RS02785 554839..555084 + 246 WP_032710460.1 hypothetical protein -
CEQ05_RS02790 555142..555978 + 837 WP_015370130.1 hypothetical protein -
CEQ05_RS02795 556072..556305 + 234 WP_015370129.1 DUF905 domain-containing protein -
CEQ05_RS02800 556403..557221 + 819 WP_015370128.1 DUF945 domain-containing protein -
CEQ05_RS02805 557221..557475 + 255 WP_071647618.1 hypothetical protein -
CEQ05_RS02810 557492..557971 + 480 WP_032710462.1 antirestriction protein -
CEQ05_RS02815 557983..558462 + 480 WP_015370126.1 DNA repair protein RadC -
CEQ05_RS02820 558483..558704 + 222 WP_015370125.1 DUF987 domain-containing protein -
CEQ05_RS02825 558673..559071 + 399 WP_127175768.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
CEQ05_RS02830 559124..559453 + 330 WP_015370123.1 TA system toxin CbtA family protein Toxin
CEQ05_RS02835 559859..559960 + 102 Protein_540 preprotein translocase -
CEQ05_RS02840 560119..560919 - 801 WP_015370122.1 nucleotidyltransferase domain-containing protein -
CEQ05_RS02845 561095..561631 - 537 WP_015370121.1 dihydrofolate reductase family protein -
CEQ05_RS02850 561831..562193 - 363 WP_015370120.1 cupin domain-containing protein -
CEQ05_RS02855 562269..563087 - 819 WP_032706441.1 AraC family transcriptional regulator -
CEQ05_RS02860 563415..563642 - 228 WP_071647620.1 DUF1272 domain-containing protein -
CEQ05_RS27180 563933..564085 + 153 WP_157844032.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 533973..563087 29114


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-107)

Antitoxin

Antitoxin CbeA

(33-131)


Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12493.28 Da        Isoelectric Point: 7.3984

>T109995 WP_015370123.1 NZ_CP031756:559124-559453 [Klebsiella aerogenes]
MQTLSLHPTRATQPYLSPVETWQRLLTHLLSEHYGLTLNDTPFSYETTIREHIDAGVSLSDAVNFLVEKYGLVRIDRKGF
SWQEQTPYISVVDILMARRSTGLLKTTVK

Download         Length: 330 bp

>T109995 NZ_CP031756:559124-559453 [Klebsiella aerogenes]
ATGCAAACCTTATCATTACACCCGACAAGGGCGACTCAGCCCTATCTGTCACCCGTTGAAACCTGGCAACGGCTGCTGAC
TCATCTTTTATCGGAGCACTATGGCCTGACGCTGAATGACACACCGTTCAGTTATGAAACCACCATACGGGAACATATTG
ATGCAGGAGTATCGCTCAGCGATGCGGTGAACTTTCTGGTAGAAAAATACGGGCTTGTCCGTATCGACCGGAAAGGATTT
TCATGGCAAGAACAGACCCCGTATATTTCCGTAGTAGATATTCTGATGGCAAGGCGCTCGACCGGCCTGCTAAAAACTAC
CGTGAAATAA

Antitoxin


Download         Length: 133 a.a.        Molecular weight: 14730.76 Da        Isoelectric Point: 7.0372

>AT109995 WP_127175768.1 NZ_CP031756:558673-559071 [Klebsiella aerogenes]
MSSCAASRSINVNLRKAKLSNEIPAVNHDIAEPWWGLKTTVTPYFGARLVQEGNRLHYLADRASITGTFSDADLRHLDQA
FPVLLKQLELMLVSGELTSRHQHRITLYHNGLTCEADTLGSCGYVYIAIYPD

Download         Length: 399 bp

>AT109995 NZ_CP031756:558673-559071 [Klebsiella aerogenes]
ATGTCGTCCTGCGCAGCGTCACGCTCAATTAACGTTAATTTAAGGAAAGCTAAATTGTCGAATGAAATACCGGCAGTAAA
CCACGATATTGCCGAACCCTGGTGGGGACTCAAAACCACCGTCACGCCGTACTTTGGCGCACGACTGGTGCAGGAAGGCA
ACCGGCTGCATTACCTGGCTGATCGTGCCAGTATCACCGGGACATTCAGCGACGCGGATTTACGCCATCTCGACCAGGCG
TTTCCGGTATTGCTTAAACAGCTGGAGTTGATGCTCGTTTCCGGTGAGCTCACCTCCCGCCATCAGCACCGCATCACGCT
ATATCACAATGGACTGACTTGCGAAGCCGATACACTCGGCTCTTGTGGTTACGTCTACATCGCTATTTATCCCGACTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References