Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-Phd
Location 26978..27621 Replicon plasmid p.C
Accession NZ_CP031754
Organism Cereibacter sphaeroides strain EBL0706

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag D0Z66_RS21650 Protein ID WP_117345303.1
Coordinates 27220..27621 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag D0Z66_RS21645 Protein ID WP_108222755.1
Coordinates 26978..27220 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D0Z66_RS21625 23593..23874 + 282 Protein_21 transposase -
D0Z66_RS21630 23962..24294 - 333 WP_108222752.1 stability/partitioning determinant -
D0Z66_RS21635 24291..24968 - 678 WP_108222753.1 ParA family protein -
D0Z66_RS21640 25269..26297 - 1029 WP_108222754.1 replication initiator protein A -
D0Z66_RS21645 26978..27220 + 243 WP_108222755.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
D0Z66_RS21650 27220..27621 + 402 WP_117345303.1 type II toxin-antitoxin system VapC family toxin Toxin
D0Z66_RS21655 27759..28454 + 696 WP_108222601.1 recombinase family protein -
D0Z66_RS21660 28581..28961 + 381 WP_108222600.1 XRE family transcriptional regulator -
D0Z66_RS21665 28921..29697 + 777 WP_108222599.1 RES family NAD+ phosphorylase -
D0Z66_RS21670 32083..32376 - 294 WP_108222598.1 CRISPR-associated endonuclease Cas2 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..43846 43846


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-119)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-47)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14706.71 Da        Isoelectric Point: 4.8948

>T109994 WP_117345303.1 NZ_CP031754:27220-27621 [Cereibacter sphaeroides]
MYLLDTNVISAVRRPDRAPQVAAWLAGRNEADLFLSVITLGEIERGITRQEQGNPAFAADLQAWLDRTMRLFSDRILPFE
AEDARIWGRLSSRIGHNGADLMIAATALARGAVVVTGNVDDFRPTGVRIEDPF

Download         Length: 402 bp

>T109994 NZ_CP031754:27220-27621 [Cereibacter sphaeroides]
ATGTATCTGCTCGACACCAATGTCATCTCGGCGGTTCGCCGTCCCGACCGTGCACCCCAGGTGGCGGCCTGGCTTGCGGG
TCGAAACGAGGCGGATCTGTTCCTGAGCGTCATCACCCTGGGCGAGATCGAGCGTGGCATCACCCGCCAGGAGCAGGGCA
ACCCTGCCTTTGCCGCTGACCTTCAGGCATGGCTCGACAGGACGATGCGCCTCTTCTCCGATCGCATCCTGCCCTTCGAG
GCAGAGGATGCCCGGATCTGGGGCAGGCTCTCAAGCCGGATCGGGCACAACGGAGCTGACCTCATGATCGCCGCAACGGC
CCTAGCTCGAGGCGCGGTCGTGGTGACGGGGAATGTTGACGACTTCCGGCCGACCGGCGTCCGGATCGAAGATCCCTTCT
GA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8708.84 Da        Isoelectric Point: 6.4604

>AT109994 WP_108222755.1 NZ_CP031754:26978-27220 [Cereibacter sphaeroides]
MWTLQDAKNRFSSVVEAALAGVPQEVSRRGRPAVVVLSVEEYHRLLSGAQGNRGSFADHLMAFPGDGLERAEVVPRDVGF

Download         Length: 243 bp

>AT109994 NZ_CP031754:26978-27220 [Cereibacter sphaeroides]
ATGTGGACGCTTCAGGACGCCAAGAACAGGTTCAGCTCGGTGGTTGAGGCAGCCTTGGCCGGCGTGCCGCAAGAGGTTTC
CCGCCGGGGACGCCCTGCGGTGGTCGTCTTGTCGGTCGAGGAATACCACAGGCTGCTGTCCGGCGCGCAAGGCAACCGCG
GCAGCTTCGCCGATCATCTCATGGCTTTCCCCGGCGATGGTCTGGAGCGTGCCGAGGTGGTGCCCCGGGATGTCGGGTTC
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References