Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 11367..11983 Replicon plasmid p.C
Accession NZ_CP031754
Organism Cereibacter sphaeroides strain EBL0706

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag D0Z66_RS21585 Protein ID WP_108222584.1
Coordinates 11367..11774 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag D0Z66_RS21590 Protein ID WP_181318578.1
Coordinates 11774..11983 (-) Length 70 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D0Z66_RS21560 6900..7679 + 780 WP_108222589.1 recombinase family protein -
D0Z66_RS21565 7980..8381 - 402 WP_108222588.1 hypothetical protein -
D0Z66_RS21570 8400..8663 - 264 WP_108222587.1 type II toxin-antitoxin system prevent-host-death family antitoxin -
D0Z66_RS22305 8744..8908 - 165 WP_181318579.1 hypothetical protein -
D0Z66_RS21575 9091..9399 + 309 WP_108222586.1 hypothetical protein -
D0Z66_RS21580 9917..11080 - 1164 WP_108222585.1 DUF4268 domain-containing protein -
D0Z66_RS21585 11367..11774 - 408 WP_108222584.1 tRNA(fMet)-specific endonuclease VapC Toxin
D0Z66_RS21590 11774..11983 - 210 WP_181318578.1 antitoxin Antitoxin
D0Z66_RS21595 12175..12702 + 528 WP_108222583.1 hypothetical protein -
D0Z66_RS21600 12866..14647 + 1782 WP_108222582.1 DUF927 domain-containing protein -
D0Z66_RS21605 14969..15133 + 165 Protein_16 IS5/IS1182 family transposase -
D0Z66_RS22060 15532..16680 + 1149 WP_146172339.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..43846 43846


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-125)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 14941.25 Da        Isoelectric Point: 7.3602

>T109993 WP_108222584.1 NZ_CP031754:c11774-11367 [Cereibacter sphaeroides]
MLRYMLDTNILIYTIRNRPGEVRAKFEAHHGTMCISTVTAMELIFGAQKSQAVERNMAAVEGLLARLDILDLDLAAAQHA
GEIRAQLARAGTPIGPFDVMIAGHARSRGLVLVSNNTREFERVDGLRLENWVQPS

Download         Length: 408 bp

>T109993 NZ_CP031754:c11774-11367 [Cereibacter sphaeroides]
ATGCTGCGCTACATGCTCGACACGAACATCCTGATCTACACGATCAGGAACCGGCCTGGCGAGGTCAGGGCGAAATTCGA
GGCCCACCATGGGACGATGTGCATCTCGACCGTAACCGCGATGGAACTGATCTTCGGCGCGCAGAAATCGCAGGCCGTCG
AACGCAACATGGCGGCGGTCGAGGGACTTCTTGCGCGCCTCGACATCCTGGATCTCGACTTGGCGGCTGCCCAGCACGCT
GGGGAGATCCGGGCGCAGTTGGCGAGGGCAGGGACGCCCATCGGACCGTTCGACGTGATGATCGCCGGACACGCGCGATC
GAGGGGCCTGGTCCTCGTGAGCAACAACACGCGGGAATTCGAGCGCGTCGACGGCCTGAGGCTTGAGAACTGGGTCCAGC
CGTCCTGA

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 8017.86 Da        Isoelectric Point: 4.2683

>AT109993 WP_181318578.1 NZ_CP031754:c11983-11774 [Cereibacter sphaeroides]
MNNRTQAIRLPKSVALPEGTRSVDIVRLGRAWLIVPSQDSWAQWFDEVSSSEDFMERREQPDADERDDL

Download         Length: 210 bp

>AT109993 NZ_CP031754:c11983-11774 [Cereibacter sphaeroides]
ATGAACAACCGGACGCAGGCCATCCGCCTGCCGAAATCGGTTGCCCTGCCGGAAGGCACGCGGAGCGTCGACATAGTCCG
GCTGGGCAGGGCTTGGCTCATCGTGCCGAGCCAGGACAGTTGGGCTCAGTGGTTCGATGAGGTCTCGTCGAGTGAAGACT
TCATGGAGCGCCGGGAGCAACCGGACGCTGATGAACGCGACGATCTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References