Detailed information of TA system TA109992

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-CC2985
• Location: 261649..262195
• Replicon: plasmid p.A
• Accession: NZ_CP031752
• Organism: Cereibacter sphaeroides strain EBL0706

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: D0Z66_RS20735
• Protein ID: WP_011910870.1
• Coordinates: 261649..261942 (-)
• Length: 98 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: D0Z66_RS20740
• Protein ID: WP_011910869.1
• Coordinates: 261929..262195 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D0Z66_RS22275	256860..257003	-	144	WP_181969655.1	hypothetical protein	-
D0Z66_RS20715	257218..258420	+	1203	WP_117345263.1	Fic family protein	-
D0Z66_RS20720	258514..259746	-	1233	WP_181969656.1	AAA family ATPase	-
D0Z66_RS20725	260352..260771	+	420	WP_011910872.1	hypothetical protein	-
D0Z66_RS20730	261316..261564	-	249	WP_011910871.1	AzlD domain-containing protein	-
D0Z66_RS20735	261649..261942	-	294	WP_011910870.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
D0Z66_RS20740	261929..262195	-	267	WP_011910869.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
D0Z66_RS20750	262871..263695	+	825	Protein_249	hypothetical protein	-
D0Z66_RS20760	264713..266044	-	1332	WP_011910866.1	HipA domain-containing protein	-
D0Z66_RS20765	266044..266355	-	312	WP_080517499.1	helix-turn-helix transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..298364	298364

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-92)

Antitoxin

• Antitoxin ParD (2-80)

Sequences

Toxin

Protein

• Length: 98 a.a.
• Molecular weight: 11036.64 Da
• Isoelectric Point: 7.4636

>T109992 WP_011910870.1 NZ_CP031752:c261942-261649 [Cereibacter sphaeroides]
VTKIDFTRDAERDLIDIFLYGIEHFGPVQAERYTKTLNAKIDMAAEHPDFGADYGFVIKGVRRYEAVSHAIYYRSTGVGI
LVLRVLHGRMDPARHLA

Nucleotide

• Length: 294 bp

>T109992 NZ_CP031752:c261942-261649 [Cereibacter sphaeroides]
GTGACGAAAATTGACTTCACGCGTGATGCCGAACGGGACCTGATCGACATCTTCCTCTACGGGATCGAACATTTCGGCCC
GGTTCAGGCCGAGAGGTACACGAAGACGCTCAACGCCAAGATCGACATGGCGGCAGAGCATCCAGATTTTGGGGCTGACT
ACGGCTTCGTTATCAAGGGTGTTCGCAGGTACGAGGCTGTGTCCCACGCTATATACTACCGCTCTACAGGGGTAGGTATT
CTCGTGCTGCGCGTCCTGCACGGCCGGATGGATCCGGCCCGTCATCTGGCTTGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10073.22 Da
• Isoelectric Point: 4.7064

>AT109992 WP_011910869.1 NZ_CP031752:c262195-261929 [Cereibacter sphaeroides]
MSRLTISMPDQMNEWVEAQIAAGRYGNVSEYFRDLVRRDQERREAAVAELRTMLERADASGVSDRSFPDILEAARREARQ
KGLLGDEN

Nucleotide

• Length: 267 bp

>AT109992 NZ_CP031752:c262195-261929 [Cereibacter sphaeroides]
ATGTCCAGACTGACCATCTCGATGCCCGACCAGATGAACGAGTGGGTCGAGGCGCAGATCGCGGCGGGCCGTTACGGTAA
CGTCAGCGAGTACTTCCGGGACCTGGTACGGCGTGACCAAGAGCGCAGGGAAGCGGCCGTTGCCGAGCTCCGGACCATGC
TTGAGCGCGCGGACGCGAGCGGTGTCTCTGATCGCTCCTTCCCAGATATCCTGGAGGCGGCGCGCCGGGAGGCCCGACAA
AAGGGTCTGCTTGGTGACGAAAATTGA