Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/MazF(toxin)
Location 3044413..3045064 Replicon chromosome
Accession NZ_CP031739
Organism Psychrobacillus sp. AK 1817

Toxin (Protein)


Gene name pemK Uniprot ID -
Locus tag D0S48_RS15215 Protein ID WP_151112496.1
Coordinates 3044714..3045064 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID -
Locus tag D0S48_RS15210 Protein ID WP_144539611.1
Coordinates 3044413..3044709 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D0S48_RS15185 3039444..3040943 + 1500 WP_151112494.1 PH domain-containing protein -
D0S48_RS15190 3040988..3041617 - 630 WP_144539603.1 rhomboid family intramembrane serine protease -
D0S48_RS15195 3041686..3042039 + 354 WP_144539605.1 holo-ACP synthase -
D0S48_RS15200 3042138..3043118 + 981 WP_186318211.1 outer-membrane lipoprotein carrier protein LolA -
D0S48_RS15205 3043188..3044297 + 1110 WP_144539609.1 alanine racemase -
D0S48_RS15210 3044413..3044709 + 297 WP_144539611.1 transcriptional regulator Antitoxin
D0S48_RS15215 3044714..3045064 + 351 WP_151112496.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
D0S48_RS15220 3045365..3046192 + 828 WP_151112498.1 STAS domain-containing protein -
D0S48_RS15225 3046189..3046554 + 366 WP_191697910.1 STAS domain-containing protein -
D0S48_RS15230 3046561..3046962 + 402 WP_144539620.1 anti-sigma regulatory factor -
D0S48_RS15235 3046975..3047976 + 1002 WP_144539622.1 PP2C family protein-serine/threonine phosphatase -
D0S48_RS15240 3048046..3048387 + 342 WP_144539624.1 STAS domain-containing protein -
D0S48_RS15245 3048374..3048844 + 471 WP_144539626.1 anti-sigma B factor RsbW -
D0S48_RS15250 3048822..3049604 + 783 WP_144539628.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12886.80 Da        Isoelectric Point: 4.7222

>T109988 WP_151112496.1 NZ_CP031739:3044714-3045064 [Psychrobacillus sp. AK 1817]
MIVKRGDVFFADLSPVVGSEQGGTRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKEYDFERDSVILLEQL
RTIDKSRLTDKITHLDEDVMEEVDHALGISLGIVKF

Download         Length: 351 bp

>T109988 NZ_CP031739:3044714-3045064 [Psychrobacillus sp. AK 1817]
TTGATCGTAAAACGTGGGGACGTTTTTTTTGCAGATTTATCACCAGTAGTCGGGTCTGAACAAGGTGGAACTAGGCCCGT
ACTGGTGATACAAAATGATATCGGAAATCGGTTTAGTCCGACTGTAATTGTGGCAGCGATTACCGCTCAGATACAAAAAG
CGAAATTGCCGACACATGTAGAAATCGATGCAAAAGAGTATGATTTTGAACGTGATTCAGTTATATTATTAGAACAGTTA
CGAACTATTGATAAGTCAAGGCTTACGGATAAAATCACACACTTAGATGAAGATGTGATGGAAGAAGTCGATCATGCACT
AGGCATCAGCTTAGGAATCGTAAAATTTTAA

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 10961.68 Da        Isoelectric Point: 6.8617

>AT109988 WP_144539611.1 NZ_CP031739:3044413-3044709 [Psychrobacillus sp. AK 1817]
MSEVFAVVSDKKKKEALIEIPMQMVSEGVQTSKSLTGRESVARVHANEYMKKGQANLIREAMMKGYVEMSHINLSICMEC
LHAEYEAQHTTERLVSGG

Download         Length: 297 bp

>AT109988 NZ_CP031739:3044413-3044709 [Psychrobacillus sp. AK 1817]
TTGTCGGAGGTGTTTGCTGTGGTAAGTGATAAAAAGAAAAAAGAAGCGCTTATAGAGATTCCAATGCAAATGGTTAGTGA
GGGAGTGCAAACTTCTAAATCATTAACTGGTAGGGAAAGCGTTGCTCGTGTACATGCAAATGAATATATGAAGAAAGGCC
AGGCAAATCTTATAAGAGAAGCGATGATGAAAGGTTATGTTGAGATGTCTCATATTAACTTATCCATATGTATGGAATGT
CTACATGCGGAATATGAAGCCCAACATACGACAGAGCGACTCGTAAGTGGAGGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References