Detailed information of TA system TA109987

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RelB(antitoxin)
• Location: 1639868..1640480
• Replicon: chromosome
• Accession: NZ_CP031738
• Organism: Streptococcus pyogenes strain SP1336

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: D0Z58_RS08530
• Protein ID: WP_129796265.1
• Coordinates: 1640145..1640480 (+)
• Length: 112 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: Q5X9X9
• Locus tag: D0Z58_RS08525
• Protein ID: WP_002988079.1
• Coordinates: 1639868..1640155 (+)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D0Z58_RS08500	1635059..1636042	-	984	WP_002988088.1	tagatose-bisphosphate aldolase	-
D0Z58_RS08505	1636046..1636975	-	930	WP_002988085.1	tagatose-6-phosphate kinase	-
D0Z58_RS08510	1637021..1637536	-	516	WP_002988082.1	galactose-6-phosphate isomerase subunit LacB	-
D0Z58_RS08515	1637571..1637999	-	429	WP_002982747.1	galactose-6-phosphate isomerase subunit LacA	-
D0Z58_RS08520	1638445..1639218	+	774	WP_002982738.1	DeoR/GlpR family DNA-binding transcription regulator	-
D0Z58_RS08525	1639868..1640155	+	288	WP_002988079.1	DNA-damage-inducible protein J	Antitoxin
D0Z58_RS08530	1640145..1640480	+	336	WP_129796265.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
D0Z58_RS09775	1640632..1641102	+	471	WP_002988074.1	integrase	-
D0Z58_RS09780	1641065..1641427	+	363	WP_180373113.1	tyrosine-type recombinase/integrase	-
D0Z58_RS09785	1641463..1641612	+	150	WP_002982720.1	hypothetical protein	-
D0Z58_RS08540	1641732..1642124	-	393	WP_002982716.1	30S ribosomal protein S9	-
D0Z58_RS08545	1642145..1642591	-	447	WP_002982710.1	50S ribosomal protein L13	-
D0Z58_RS08550	1642809..1643015	-	207	WP_002982695.1	helix-turn-helix transcriptional regulator	-
D0Z58_RS08555	1643012..1643518	-	507	WP_002988070.1	hypothetical protein	-
D0Z58_RS08560	1643654..1644514	-	861	WP_002982687.1	DegV family protein	-
D0Z58_RS08565	1644611..1645129	-	519	WP_002982682.1	NYN domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (7-107)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 112 a.a.
• Molecular weight: 13143.91 Da
• Isoelectric Point: 5.2144

>T109987 WP_129796265.1 NZ_CP031738:1640145-1640480 [Streptococcus pyogenes]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTLGQRKMEQIISDIEKLEVFPEVGFDADEKYGSKISHYHSTKGYTLSKD
YIVLYHIEGEENRVAIDYLLPTQSDYIKLFK

Nucleotide

• Length: 336 bp

>T109987 NZ_CP031738:1640145-1640480 [Streptococcus pyogenes]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGCTAAAAGAAATTCGTGATTATATTTCTCA
AAACTACTCCTCAACATTAGGTCAGCGTAAAATGGAGCAAATCATTAGCGACATAGAAAAACTCGAGGTTTTCCCAGAAG
TTGGTTTTGATGCCGATGAAAAATATGGTTCAAAAATCAGCCATTATCACAGCACTAAAGGTTACACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAGGGGGAAGAAAATAGGGTCGCTATTGATTACTTGCTTCCTACTCAAAGCGACTATAT
AAAGTTATTCAAATAA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10934.56 Da
• Isoelectric Point: 5.2318

>AT109987 WP_002988079.1 NZ_CP031738:1639868-1640155 [Streptococcus pyogenes]
MTTVKKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRAELGL

Nucleotide

• Length: 288 bp

>AT109987 NZ_CP031738:1639868-1640155 [Streptococcus pyogenes]
ATGACTACAGTAAAAAAAAACAGAGCGGTTACCTTTCAAGCTAATAAAGAATTGGTAAGCGAAGCAATGACAGTATTAAA
CAAAAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTACAAAATGTCGTTGTCACAAACGAGGTTGACTTATTGA
CGGAAGAGGAGTTAGAGAAAGAAAAACTTTTCAAGCAATTTCAAGCTGAAATCAACAAAAATATTGAGGACGTTCGTCAA
GGGAAGTTTTATACCTCTGAAGAAGTGAGGGCTGAACTTGGACTATAA

Structures

Antitoxin

• AlphaFold DB: A0A4U7GX94