Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 1030454..1031025 Replicon chromosome
Accession NZ_CP031733
Organism Streptococcus chenjunshii strain Z15

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag DDV21_RS05075 Protein ID WP_116877333.1
Coordinates 1030693..1031025 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag DDV21_RS05070 Protein ID WP_116877334.1
Coordinates 1030454..1030699 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DDV21_RS05045 1025995..1026315 + 321 WP_116877339.1 carboxymuconolactone decarboxylase family protein -
DDV21_RS05050 1026421..1027236 + 816 WP_116877338.1 aldo/keto reductase -
DDV21_RS05055 1027511..1028365 - 855 WP_116877337.1 LysR family transcriptional regulator -
DDV21_RS05060 1028469..1029320 + 852 WP_116877336.1 aldo/keto reductase -
DDV21_RS05065 1029385..1030242 + 858 WP_116877335.1 aldo/keto reductase -
DDV21_RS05070 1030454..1030699 + 246 WP_116877334.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
DDV21_RS05075 1030693..1031025 + 333 WP_116877333.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
DDV21_RS05080 1031463..1032254 + 792 WP_116877332.1 class I SAM-dependent methyltransferase -
DDV21_RS05085 1032472..1033947 + 1476 WP_116877331.1 family 1 glycosylhydrolase -
DDV21_RS05090 1034834..1035043 + 210 WP_116877330.1 DUF4649 family protein -
DDV21_RS05095 1035253..1035861 + 609 WP_116877329.1 DUF1349 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(5-107)

Antitoxin

SpoVT-AbrB domain

(7-49)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 12480.50 Da        Isoelectric Point: 9.7481

>T109986 WP_116877333.1 NZ_CP031733:1030693-1031025 [Streptococcus chenjunshii]
MVSIKQGSIIKISLDPKQGHEQKGYRPYICLSHSVVTKYSNIAIFAPISNTKRDYPFYVPLKGTKTTGKVLLDQLVTIDF
NARDYRYVEDVTEGLLDNLLARVKVLFEKG

Download         Length: 333 bp

>T109986 NZ_CP031733:1030693-1031025 [Streptococcus chenjunshii]
ATGGTAAGTATTAAACAGGGCTCCATTATTAAAATTAGCCTTGACCCCAAGCAGGGGCATGAGCAAAAGGGATATCGTCC
TTACATTTGTTTAAGTCATAGTGTTGTCACCAAATATTCAAATATTGCCATCTTTGCCCCAATCAGTAATACCAAACGTG
ACTATCCCTTTTATGTTCCGTTAAAAGGGACGAAAACAACTGGAAAAGTCCTGCTGGACCAATTGGTGACCATTGACTTT
AATGCCAGAGATTACCGCTATGTAGAGGATGTTACAGAGGGATTATTAGATAATCTGCTAGCCCGTGTAAAAGTATTATT
TGAAAAAGGCTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9325.69 Da        Isoelectric Point: 4.7063

>AT109986 WP_116877334.1 NZ_CP031733:1030454-1030699 [Streptococcus chenjunshii]
MQLTVNKWGNSSAIRLPKQLVQQLQLQVNDVLDYKVSGNKIILEKVATVPELTVEELFKDYQGEPVDVTPVLFERRGNEQ
W

Download         Length: 246 bp

>AT109986 NZ_CP031733:1030454-1030699 [Streptococcus chenjunshii]
ATGCAACTGACAGTTAATAAATGGGGAAATAGTTCTGCTATCAGGCTTCCCAAGCAGCTTGTTCAGCAATTGCAGCTGCA
GGTAAATGATGTGCTTGATTATAAAGTTTCTGGCAATAAAATTATTTTAGAAAAGGTGGCAACGGTACCTGAACTGACCG
TTGAAGAACTCTTTAAAGATTATCAAGGAGAACCTGTAGATGTGACTCCCGTCTTGTTTGAAAGAAGGGGCAATGAACAA
TGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References