Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/ElaA-DUF1778
Location 8888..9627 Replicon plasmid p2_020038
Accession NZ_CP031723
Organism Enterobacter hormaechei strain WCHEH020038

Toxin (Protein)


Gene name tacT Uniprot ID A0A9E6WPH7
Locus tag D0Z05_RS00755 Protein ID WP_013087269.1
Coordinates 8888..9373 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A9E6WPN8
Locus tag D0Z05_RS00760 Protein ID WP_007869691.1
Coordinates 9361..9627 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D0Z05_RS00740 5352..5990 + 639 WP_008786709.1 DUF2913 family protein -
D0Z05_RS00745 6124..6954 + 831 WP_100135202.1 hypothetical protein -
D0Z05_RS00750 7703..8521 + 819 WP_013087268.1 abortive infection family protein -
D0Z05_RS00755 8888..9373 - 486 WP_013087269.1 GNAT family N-acetyltransferase Toxin
D0Z05_RS00760 9361..9627 - 267 WP_007869691.1 DUF1778 domain-containing protein Antitoxin
D0Z05_RS00770 10280..11293 + 1014 WP_013087098.1 replication initiation protein -
D0Z05_RS00780 12244..13050 + 807 WP_013087100.1 DUF4225 domain-containing protein -
D0Z05_RS00785 13025..13354 - 330 WP_013087101.1 hypothetical protein -
D0Z05_RS00790 13437..13775 - 339 WP_013087102.1 hypothetical protein -
D0Z05_RS00795 13790..14560 - 771 WP_013087103.1 conjugal transfer protein TraX -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid tet(D) / dfrA14 / sul2 / aph(3'')-Ib / aph(6)-Id / blaTEM-1B - 1..88009 88009


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(45-146)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17736.45 Da        Isoelectric Point: 9.5181

>T109960 WP_013087269.1 NZ_CP031723:c9373-8888 [Enterobacter hormaechei]
VGRVTAPEPLSSSHQLAEFVSGEAVLDDWLKQRGLKNQALGAARTFVVCKRDTKQVVGFYSLATGSVNHVEAMGSLRRNM
PDPIPVIILARLAVDVSYRGQGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYLHHGFKASQTQERTLFLKLP
Q

Download         Length: 486 bp

>T109960 NZ_CP031723:c9373-8888 [Enterobacter hormaechei]
GTGGGACGTGTAACAGCACCAGAACCATTATCCAGCTCCCATCAACTAGCAGAGTTCGTCAGTGGTGAGGCAGTACTTGA
TGACTGGCTTAAACAGAGGGGATTAAAAAACCAAGCTCTTGGTGCAGCACGAACGTTCGTCGTTTGTAAAAGAGACACTA
AACAGGTTGTCGGTTTTTACTCTCTGGCCACCGGCAGCGTTAACCACGTGGAAGCAATGGGAAGCCTCAGGCGCAATATG
CCAGATCCAATTCCCGTAATCATACTTGCTCGCCTGGCAGTTGATGTTTCATACCGTGGCCAAGGGCTCGGGGCCGATTT
ACTGCATGATGCAGTTCTGCGCTGTTACCGTGTAGCTGAGAATATTGGAGTCCGTGCGATTATGGTTCATGCACTGACTG
AAGAAGCCAAAAACTTTTATCTTCACCATGGCTTTAAGGCATCACAAACTCAGGAACGGACATTGTTTTTAAAGTTACCA
CAGTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10080.46 Da        Isoelectric Point: 4.3837

>AT109960 WP_007869691.1 NZ_CP031723:c9627-9361 [Enterobacter hormaechei]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVSDEAAIDKLL
ARKPQWDV

Download         Length: 267 bp

>AT109960 NZ_CP031723:c9627-9361 [Enterobacter hormaechei]
ATGAAATCAGATGTTCAGCTCAACCTTAGAGCTAAAGAATCTCAAAGAGCACTTATTGATGCTGCAGCAGAGATTCTCCA
TAAATCACGCACGGACTTCATCCTGGAAATGGCATGTCAGGCTGCGGAGAATGTGATCCTCGATCGTCGCGTATTTAATT
TTAACGATGAGCAGTATGCAGAGTTTATCGATATGCTCGATGCACCGGTTTCGGATGAGGCGGCTATTGATAAACTTCTG
GCAAGGAAACCTCAGTGGGACGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References