Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-paaA/RelE(toxin)
Location 3018936..3019386 Replicon chromosome
Accession NZ_CP031716
Organism Acinetobacter wuhouensis strain WCHA60

Toxin (Protein)


Gene name relE Uniprot ID A0A385C6N3
Locus tag BEN71_RS15015 Protein ID WP_068974807.1
Coordinates 3019111..3019386 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID A0A385C6H6
Locus tag BEN71_RS15010 Protein ID WP_068974806.1
Coordinates 3018936..3019124 (+) Length 63 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BEN71_RS14970 3014332..3015627 - 1296 WP_068974798.1 iron-sulfur cluster carrier protein ApbC -
BEN71_RS14975 3016112..3016405 - 294 WP_068974799.1 hypothetical protein -
BEN71_RS14980 3016544..3016843 + 300 WP_068974800.1 hypothetical protein -
BEN71_RS14985 3016889..3017077 - 189 WP_068974801.1 hypothetical protein -
BEN71_RS14990 3017286..3017510 + 225 WP_068974802.1 hypothetical protein -
BEN71_RS14995 3017500..3017847 + 348 WP_068974803.1 hypothetical protein -
BEN71_RS15000 3017858..3018172 - 315 WP_068974804.1 antibiotic biosynthesis monooxygenase -
BEN71_RS15005 3018227..3018742 - 516 WP_068974805.1 hypothetical protein -
BEN71_RS15010 3018936..3019124 + 189 WP_068974806.1 antitoxin Antitoxin
BEN71_RS15015 3019111..3019386 + 276 WP_068974807.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BEN71_RS15020 3019419..3020249 - 831 WP_068974821.1 hypothetical protein -
BEN71_RS15025 3020440..3022497 + 2058 WP_068974808.1 methionine--tRNA ligase -
BEN71_RS15030 3023210..3024001 + 792 WP_068974809.1 segregation/condensation protein A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-89)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10510.09 Da        Isoelectric Point: 5.0233

>T109929 WP_068974807.1 NZ_CP031716:3019111-3019386 [Acinetobacter wuhouensis]
MLTVNWKINAVHDLEEIIDYIFIQNPGAAINLEDEILNTAESLADMPYSGRIGRVSGTRERIVHPNYMIIYQLLFDSIEI
LNIVHTKKHYP

Download         Length: 276 bp

>T109929 NZ_CP031716:3019111-3019386 [Acinetobacter wuhouensis]
ATGTTGACCGTTAACTGGAAAATAAACGCTGTTCATGACTTAGAGGAAATTATTGATTATATTTTCATTCAAAACCCTGG
AGCCGCAATAAATCTCGAAGATGAAATTTTAAATACGGCTGAGAGCCTTGCTGATATGCCATACAGTGGGCGTATAGGTC
GAGTTTCTGGGACGAGAGAAAGGATCGTACATCCCAATTACATGATTATTTATCAGCTTTTATTTGATTCAATTGAAATT
CTCAATATCGTACATACAAAAAAGCATTATCCATAA

Antitoxin


Download         Length: 63 a.a.        Molecular weight: 7544.34 Da        Isoelectric Point: 4.4678

>AT109929 WP_068974806.1 NZ_CP031716:3018936-3019124 [Acinetobacter wuhouensis]
MNEVFDPFVSEFDDADMEQNYNEWLKNKVEQSIVDSRPSISHDQVIERMKQKREERLKNVDR

Download         Length: 189 bp

>AT109929 NZ_CP031716:3018936-3019124 [Acinetobacter wuhouensis]
ATGAATGAAGTATTTGATCCTTTCGTGTCAGAATTTGACGATGCGGATATGGAACAAAATTACAATGAATGGCTGAAAAA
CAAAGTTGAACAGTCTATTGTCGATTCACGCCCATCCATTTCACATGATCAAGTTATTGAACGCATGAAGCAAAAGCGCG
AAGAAAGATTAAAAAATGTTGACCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A385C6N3

Antitoxin

Source ID Structure
AlphaFold DB A0A385C6H6

References