Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 359418..360992 Replicon chromosome
Accession NZ_CP031704
Organism Solimonas sp. K1W22B-7

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag D0B54_RS01765 Protein ID WP_117288625.1
Coordinates 359673..360992 (+) Length 440 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag D0B54_RS01760 Protein ID WP_117288623.1
Coordinates 359418..359669 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D0B54_RS01735 356100..357113 - 1014 WP_162932135.1 DNA cytosine methyltransferase -
D0B54_RS01740 357133..357372 - 240 WP_117288618.1 hypothetical protein -
D0B54_RS01745 357614..358090 - 477 WP_117288620.1 hypothetical protein -
D0B54_RS01750 358361..358600 + 240 WP_117294971.1 type II toxin-antitoxin system ParD family antitoxin -
D0B54_RS01755 358597..358893 + 297 WP_117288622.1 type II toxin-antitoxin system RelE/ParE family toxin -
D0B54_RS01760 359418..359669 + 252 WP_117288623.1 helix-turn-helix domain-containing protein Antitoxin
D0B54_RS01765 359673..360992 + 1320 WP_117288625.1 type II toxin-antitoxin system HipA family toxin Toxin
D0B54_RS01770 361201..361944 + 744 WP_117288627.1 3-oxoacyl-ACP reductase FabG -
D0B54_RS01775 361970..363136 + 1167 WP_117288629.1 MaoC family dehydratase N-terminal domain-containing protein -
D0B54_RS01780 363294..364193 - 900 WP_117288631.1 HpcH/HpaI aldolase/citrate lyase family protein -
D0B54_RS01785 364186..365271 - 1086 WP_117288633.1 cysteine protease StiP family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(155-389)

Antitoxin

Cro/C1-type helix-turn-helix domain

(12-66)


Sequences

Toxin        


Download         Length: 440 a.a.        Molecular weight: 47701.84 Da        Isoelectric Point: 9.6798

>T109890 WP_117288625.1 NZ_CP031704:359673-360992 [Solimonas sp. K1W22B-7]
MARPSSSRALAVWMNGERVGTWTTRAGRPDEFGYASEWLAAGAARPLSLSMPLGPGGYKGEAVSAFFDNLLPDSRGIRER
IQRRFGASSTGAFDLLAEIGRDCVGAIQLLPEGSAAPDVRKIEGTPLTARQVDGLLADMLGAPIGRAGGDEGFRISLAGA
QEKTALLRQGGKWLRPRGITPTTHILKLPIGLGGGGIDLTTSVENEWLCTEIFKAYGLPAANCWMDRFGERKLLVVERFD
RRLSQDGRWIVRLPQEDLCQATGVPADSKYESDGGPGILRIMDLLLGSSHSAADRRRFLKTQMLFWMLCAIDGHAKNFSL
FLEAGGGYRLTPLYDVLSAHPVLGNSRGQLPPRKVKMAMAVEGTSRHYLWHTIQPRHWEETARRAGMAAAYPEFRAELIE
ATPAVVEKLAAQLPKGFPQAVAGPIFKGLRAASEMLARG

Download         Length: 1320 bp

>T109890 NZ_CP031704:359673-360992 [Solimonas sp. K1W22B-7]
ATGGCCCGGCCATCTTCGAGCCGCGCCCTTGCCGTGTGGATGAACGGGGAGCGCGTGGGCACATGGACGACGCGCGCCGG
CAGGCCGGACGAGTTCGGCTATGCCTCCGAGTGGCTGGCGGCCGGCGCCGCTCGCCCGCTCTCCTTGTCGATGCCGCTCG
GGCCTGGCGGCTACAAGGGCGAGGCGGTGTCTGCGTTCTTCGACAACCTGCTGCCCGACAGCCGGGGAATCCGCGAGCGC
ATCCAGCGGCGCTTCGGGGCGTCCTCCACTGGCGCGTTTGATCTGCTGGCCGAGATCGGGCGCGATTGCGTTGGCGCCAT
CCAGCTTTTGCCAGAGGGCAGTGCCGCTCCGGATGTGAGGAAGATAGAAGGCACTCCACTGACGGCCCGGCAGGTTGATG
GTTTGCTGGCCGACATGTTGGGCGCGCCCATAGGACGTGCCGGTGGTGATGAAGGCTTCCGTATCTCCCTGGCCGGCGCG
CAGGAGAAAACGGCGCTGCTGCGCCAGGGCGGCAAATGGCTGCGGCCCAGGGGCATCACGCCCACCACGCACATCCTGAA
GCTGCCCATTGGCCTGGGCGGCGGCGGCATCGACCTGACCACCTCCGTCGAGAACGAATGGCTCTGCACGGAGATCTTCA
AGGCGTATGGCCTGCCGGCGGCCAACTGCTGGATGGACCGGTTCGGCGAGCGCAAGCTGCTGGTCGTGGAGCGCTTTGAT
CGCCGCCTGTCGCAGGACGGACGCTGGATTGTCCGCCTGCCGCAGGAGGACCTGTGCCAGGCAACCGGTGTGCCGGCAGA
CAGCAAGTACGAATCCGACGGTGGTCCCGGCATCCTGCGGATCATGGACCTGCTGTTGGGCTCGTCGCACTCCGCCGCCG
ATCGCCGCAGGTTCCTGAAGACGCAGATGCTGTTCTGGATGCTCTGCGCCATCGACGGGCACGCCAAGAACTTCAGTCTC
TTCCTGGAAGCGGGCGGGGGCTACCGGCTCACGCCGCTGTATGACGTGCTCTCCGCGCATCCGGTGCTCGGCAACTCCCG
CGGCCAGCTTCCGCCCCGGAAAGTGAAGATGGCGATGGCGGTGGAGGGTACGAGCCGCCATTACCTCTGGCACACGATCC
AGCCGCGGCACTGGGAGGAGACAGCGCGCCGCGCCGGCATGGCGGCGGCGTATCCGGAGTTCCGGGCGGAACTGATCGAG
GCCACCCCCGCAGTGGTCGAAAAGCTGGCGGCGCAGTTGCCGAAGGGCTTTCCGCAGGCCGTTGCCGGGCCGATCTTCAA
GGGCCTGAGAGCCGCCAGCGAGATGCTGGCGCGGGGTTAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9218.52 Da        Isoelectric Point: 10.2212

>AT109890 WP_117288623.1 NZ_CP031704:359418-359669 [Solimonas sp. K1W22B-7]
MDYVARTPEQLGQLLRSCRAQRGITQSLAGAKVGLKQSTVSGIELDASRSSVETLYKLLSSLDLELVLRDKQARTPGRSQ
REW

Download         Length: 252 bp

>AT109890 NZ_CP031704:359418-359669 [Solimonas sp. K1W22B-7]
ATGGACTACGTTGCACGCACGCCAGAGCAGCTGGGGCAGCTTCTGAGAAGTTGCCGCGCCCAGCGCGGCATCACCCAGAG
CCTCGCGGGGGCCAAGGTGGGGCTGAAGCAAAGCACCGTTTCAGGCATTGAGCTCGACGCGTCGCGCAGCAGCGTTGAAA
CCCTATACAAGCTGCTGTCCTCGCTGGACCTGGAATTGGTCCTCCGCGACAAGCAGGCGAGGACTCCCGGCCGTTCGCAG
CGGGAGTGGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References