Detailed information of TA system TA109888

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YoeB-RelB
• Location: 1401759..1402267
• Replicon: chromosome
• Accession: NZ_CP031699
• Organism: Neisseria animalis strain ATCC 49930

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: D0T90_RS06505
• Protein ID: WP_123795615.1
• Coordinates: 1401759..1402019 (-)
• Length: 87 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: D0T90_RS06510
• Protein ID: WP_123795614.1
• Coordinates: 1402016..1402267 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D0T90_RS06490	1397959..1399050	+	1092	WP_123795618.1	redox-regulated ATPase YchF	-
D0T90_RS06495	1399121..1400416	+	1296	WP_123795617.1	tyrosine--tRNA ligase	-
D0T90_RS06500	1400747..1401577	+	831	WP_123795616.1	CoA ester lyase	-
D0T90_RS06505	1401759..1402019	-	261	WP_123795615.1	Txe/YoeB family addiction module toxin	Toxin
D0T90_RS06510	1402016..1402267	-	252	WP_123795614.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
D0T90_RS06515	1402521..1402721	-	201	WP_123795613.1	putative selenoprotein	-
D0T90_RS06520	1402705..1404783	-	2079	WP_123795612.1	carbon starvation protein A	-
D0T90_RS06525	1405385..1406248	-	864	WP_123795611.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (1-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (3-74)

Sequences

Toxin

Protein

• Length: 87 a.a.
• Molecular weight: 10375.71 Da
• Isoelectric Point: 7.3970

>T109888 WP_123795615.1 NZ_CP031699:c1402019-1401759 [Neisseria animalis]
MMLHFTDDAWEDYQYWLQTDKAVLKRINTIIQDMQRNPFDGIGKPEPLRHSLSGYYSRRINQEHRIVYRADDSGIWLISL
RFHYSG

Nucleotide

• Length: 261 bp

>T109888 NZ_CP031699:c1402019-1401759 [Neisseria animalis]
ATGATGTTGCACTTTACCGATGACGCATGGGAGGATTACCAATACTGGCTGCAAACAGATAAAGCTGTTCTCAAACGTAT
CAATACCATTATTCAAGACATGCAGCGCAATCCGTTTGACGGCATTGGCAAACCCGAACCGCTGCGCCACAGCTTGAGCG
GTTATTACAGCCGCCGCATCAATCAGGAACACCGCATTGTTTACCGAGCCGACGACAGCGGTATTTGGTTGATTTCTCTG
CGTTTCCATTATTCCGGCTAG

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 8878.15 Da
• Isoelectric Point: 4.7023

>AT109888 WP_123795614.1 NZ_CP031699:c1402267-1402016 [Neisseria animalis]
MYAVHASDFRKNMAATLDRVADNAEPVLITRSGASAAVLLDINEYNALIETAYLLSNPAMAARLAKGIAEVEAGKTSIRE
LVE

Nucleotide

• Length: 252 bp

>AT109888 NZ_CP031699:c1402267-1402016 [Neisseria animalis]
ATGTATGCCGTCCACGCTTCCGATTTCCGCAAAAACATGGCAGCCACGCTTGACCGCGTTGCCGACAACGCCGAACCAGT
ACTGATTACCCGAAGCGGCGCATCTGCCGCTGTTTTGCTCGACATCAACGAATACAACGCGCTGATCGAAACGGCTTATC
TGCTTTCCAATCCCGCAATGGCGGCACGTTTGGCAAAAGGTATTGCCGAAGTGGAGGCAGGCAAAACCAGTATTCGGGAA
TTGGTTGAATGA