Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1586112..1586731 Replicon chromosome
Accession NZ_CP031695
Organism Erwinia billingiae strain TH88

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag D0N50_RS07140 Protein ID WP_151036938.1
Coordinates 1586112..1586291 (+) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag D0N50_RS07145 Protein ID WP_151036939.1
Coordinates 1586321..1586731 (+) Length 137 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D0N50_RS07125 1582250..1583245 + 996 WP_013203000.1 galactose/glucose ABC transporter substrate-binding protein MglB -
D0N50_RS07130 1583342..1584862 + 1521 WP_151036937.1 galactose/methyl galactoside ABC transporter ATP-binding protein MglA -
D0N50_RS07135 1584882..1585892 + 1011 WP_013202998.1 galactose/methyl galactoside ABC transporter permease MglC -
D0N50_RS07140 1586112..1586291 + 180 WP_151036938.1 type II toxin-antitoxin system HicA family toxin Toxin
D0N50_RS07145 1586321..1586731 + 411 WP_151036939.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
D0N50_RS07150 1586791..1587657 - 867 WP_151036940.1 outer membrane permeability protein SanA -
D0N50_RS07155 1587821..1589518 - 1698 WP_013202994.1 NAD-dependent malic enzyme -
D0N50_RS07160 1589685..1590569 - 885 WP_151036941.1 cytidine deaminase -
D0N50_RS07165 1590698..1591390 - 693 WP_151036942.1 CidB/LrgB family autolysis modulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-128)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6663.86 Da        Isoelectric Point: 11.0775

>T109872 WP_151036938.1 NZ_CP031695:1586112-1586291 [Erwinia billingiae]
MDSRTLIAEIKADGWELVRVNGSHHHFRHPTKKGVVTIPHPKKDLPIKTVKSIKKQAGM

Download         Length: 180 bp

>T109872 NZ_CP031695:1586112-1586291 [Erwinia billingiae]
ATGGATAGCAGGACGTTAATCGCTGAAATCAAAGCTGACGGTTGGGAACTGGTTAGGGTAAATGGAAGTCATCATCATTT
CAGGCACCCCACCAAAAAAGGGGTAGTGACTATCCCCCATCCAAAGAAAGATTTACCCATAAAAACGGTAAAGAGTATTA
AGAAACAAGCGGGGATGTAA

Antitoxin


Download         Length: 137 a.a.        Molecular weight: 14531.49 Da        Isoelectric Point: 4.3744

>AT109872 WP_151036939.1 NZ_CP031695:1586321-1586731 [Erwinia billingiae]
MLYPIAIENGDDHHAYGVTVPDLPGCFSAGDTLEEAVNNAKEAITGHIELLIELGDDIPAVSSLSALVADSQYAGYTWAL
VDVDLARLLGGTEKINVTLPKSLIDRIDRCVATHPEFKSRSGFLAQVAIERIAKGV

Download         Length: 411 bp

>AT109872 NZ_CP031695:1586321-1586731 [Erwinia billingiae]
ATGCTATATCCAATTGCTATTGAGAACGGTGACGATCACCATGCTTACGGCGTGACCGTGCCAGATTTGCCCGGTTGTTT
TTCTGCCGGAGACACGTTAGAAGAAGCCGTTAACAATGCCAAAGAGGCGATTACTGGACATATTGAATTGCTTATCGAGC
TGGGTGACGATATTCCGGCCGTATCCTCCCTGAGCGCTCTTGTTGCCGATAGTCAGTATGCTGGCTATACCTGGGCGCTT
GTCGATGTGGACCTGGCCCGGCTCTTAGGGGGCACTGAGAAAATCAACGTGACTTTACCGAAGTCACTTATTGACCGTAT
AGATCGCTGTGTGGCCACACACCCTGAGTTTAAAAGCCGTTCTGGTTTCCTTGCTCAGGTGGCGATTGAGCGTATTGCGA
AAGGCGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References